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Metacetamol

Name: Metacetamol
Brand: TargetMol
SKU: T0914
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0914Cas No. 621-42-1

Alias 3-Acetamidophenol

Metacetamol (3-Acetamidophenol) is a derivative of acetaminophen, a non-toxic regional isomer of acetaminophen. It is an over-the-counter analgesic and antipyretic and is also used as an organic synthesis intermediate.

Metacetamol

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Purity: 99.90%

Catalog No. T0914Alias 3-AcetamidophenolCas No. 621-42-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Metacetamol AI Summary

Metacetamol has been evaluated across various biological assays, displaying a wide range of bioactivities. It does not inhibit human poliovirus in vitro but shows bioactivity in multiple other contexts. Notably, it is effective against caspase-mediated apoptosis in mouse L1210 cells, displays significant cytotoxicity with varied log(1/ID50) values, and impacts Aldehyde Dehydrogenase 1, among others. It also inhibits human CYP450 1A2 enzyme with an IC50 of 2000.0 nM, and significantly reduces sodium fluorescein uptake in OATP1B1 and OATP1B3 transporters at a 10 µM concentration. It shows antibacterial activity against Mycobacterium species with high MIC values and affects liver, kidney function markers, and hematological parameters, indicating possible toxicities. Moreover, Metacetamol demonstrates inhibitory effects on porcine heart lactate dehydrogenase (LDH), SARS-CoV-2 induced cytotoxicity at various concentrations, and influences cholesterol hydroxylation via CYP46A1. However, its effectiveness against SARS-CoV-2 differs across assays, with varied inhibition rates and IC50 values. Lastly, it shows inhibition of the human HDAC6 enzyme, albeit with differing efficacy on commercial versus custom peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Metacetamol (3-Acetamidophenol) is a derivative of acetaminophen, a non-toxic regional isomer of acetaminophen. It is an over-the-counter analgesic and antipyretic and is also used as an organic synthesis intermediate.
Synonyms	3-Acetamidophenol

Chemical Properties

Molecular Weight	151.16
Formula	C₈H₉NO₂
Cas No.	621-42-1
Smiles	CC(=O)NC1=CC(O)=CC=C1
Relative Density.	1.249 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14 mg/mL (92.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6155 mL	33.0775 mL	66.1551 mL	330.7753 mL
5 mM	1.3231 mL	6.6155 mL	13.2310 mL	66.1551 mL
10 mM	0.6616 mL	3.3078 mL	6.6155 mL	33.0775 mL
20 mM	0.3308 mL	1.6539 mL	3.3078 mL	16.5388 mL
50 mM	0.1323 mL	0.6616 mL	1.3231 mL	6.6155 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc