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Chenodeoxycholic acid (Standard)
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Catalog No. TMSM-1459Cas No. 474-25-9
Alias CDCA (Standard)
Chenodeoxycholic acid (Standard) is an analytical reference standard intended for research and quantitative applications, representing a hydrophobic primary bile acid that activates nuclear farnesoid X receptor signaling pathways involved in cholesterol homeostasis, bile acid metabolism, and lipid regulation, and is widely used for biochemical validation, metabolic studies, and analytical method development.
Chenodeoxycholic acid (Standard)
😃Good
Catalog No. TMSM-1459Alias CDCA (Standard)Cas No. 474-25-9
Chenodeoxycholic acid (Standard) is an analytical reference standard intended for research and quantitative applications, representing a hydrophobic primary bile acid that activates nuclear farnesoid X receptor signaling pathways involved in cholesterol homeostasis, bile acid metabolism, and lipid regulation, and is widely used for biochemical validation, metabolic studies, and analytical method development.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 30 mg | $48 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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| Description | Chenodeoxycholic acid (Standard) is an analytical reference standard intended for research and quantitative applications, representing a hydrophobic primary bile acid that activates nuclear farnesoid X receptor signaling pathways involved in cholesterol homeostasis, bile acid metabolism, and lipid regulation, and is widely used for biochemical validation, metabolic studies, and analytical method development. |
| Targets&IC50 | FXR:10 - 50 μM (EC50) |
| In vitro | Chenodeoxycholic acid (CDCA) functions as a potent endogenous agonist for the Farnesoid X Receptor (FXR) with an EC₅₀ ranging from 10 to 50 μM [1]. |
| In vivo | In vivo, CDCA modulates systemic cholesterol and bile acid homeostasis through the FXR-mediated negative feedback mechanism. In models of Cerebrotendinous Xanthomatosis (CTX) (where CYP27A1 is defective), exogenous administration of CDCA suppresses the abnormal accumulation of cholestanol and toxic bile acid precursors by restoring the regulatory feedback loop [1][2]. |
| Synonyms | CDCA (Standard) |
| Molecular Weight | 392.57 |
| Formula | C24H40O4 |
| Cas No. | 474-25-9 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H] |
| Relative Density. | 1.129 g/cm3. |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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