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CASK Protein, Human, Recombinant

Catalog No. TMPY-04754
Synonyms: CMG, LIN2, MRXSNA, CAMGUK, calcium/calmodulin-dependent serine protein kinase (MAGUK family), TNRC8, CAGH39, hCASK, MICPCH, FGS4

CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.

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CASK Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
50 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
Species Human
Expression System Baculovirus Insect Cells
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Accession Number O14936-4
Synonyms CMG, LIN2, MRXSNA, CAMGUK, calcium/calmodulin-dependent serine protein kinase (MAGUK family), TNRC8, CAGH39, hCASK, MICPCH, FGS4
Construction The Human CASK (O14936-4) (Ala 2-Tyr 898) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
Protein Purity > 90 % as determined by SDS-PAGE
Molecular Weight 102.1 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.

Research Background Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2 contains oneguanylate kinase-like domain, twoL27 domains, onePDZ (DHR) domain, oneprotein kinase domain and oneSH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. CASK / LIN2 is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. CASK / LIN2 contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. It binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. CASK / LIN2 may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Defects in CASK are also the cause of FG syndrome type 4 which is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.

References and Literature

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Keywords

CASK Protein, Human, Recombinant CMG LIN2 MRXSNA TNRC-8 LIN-2 CAMGUK FGS-4 calcium/calmodulin-dependent serine protein kinase (MAGUK family) TNRC8 CAGH-39 CAGH 39 CAGH39 FGS 4 MAGUK family hCASK MICPCH TNRC 8 FGS4 LIN 2 recombinant recombinant-proteins proteins protein

 

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