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PC786

Name: PC786
Brand: TargetMol
SKU: T16439
Price: 399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16439Cas No. 1902114-15-1

Alias PC 786

PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections, with antiviral activity against RSV-A (IC50=0.09-0.71 nM) and RSV-B (IC 50=1.3-50.6 nM), and the ability to inhibit RSV RNA-dependent RNA polymerase in HEp-2 cells ( RdRp).

PC786

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Purity: 99.26%

Catalog No. T16439Alias PC 786Cas No. 1902114-15-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$399	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.26%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections, with antiviral activity against RSV-A (IC50=0.09-0.71 nM) and RSV-B (IC 50=1.3-50.6 nM), and the ability to inhibit RSV RNA-dependent RNA polymerase in HEp-2 cells ( RdRp).
Targets&IC50	RSV B:1.3–50.6 nM, RSV A:<0.09–0.71 nM, RdRp (RSV, cell-free enzyme assay):14.11 μM, RdRp (RSV, minigenome assay in HEp-2 cells):0.5 nM
In vitro	PC786 exhibits strong antiviral activity against RSV-A (IC₅₀: <0.09–0.71 nM) and RSV-B (IC₅₀: 1.3–50.6 nM) in HEp-2 cells, with no detectable cytotoxicity.[1] PCR analysis confirmed inhibition of RSV replication, and PC786 potently inhibited RSV RNA-dependent RNA polymerase (RdRp) activity in both a cell-free enzyme assay (IC₅₀: 2.1 nM) and a minigenome assay in HEp-2 cells (IC₅₀: 0.5 nM).[1]
In vivo	Treatment with PC786 (either intratracheal or intranasal; Once-daily on days-1 to 3), is found to inhibit viral loads in the lungs of RSV A2-infected BALB/c mice. The viral load is below the level of detection when the drug is given at 2 mg/mL (40 μg/mouse [approximately 1.6 mg/kg of body weight] for i.t. treatment, or 80 μg/mouse [approximately 3.2 mg/kg] for i.n. treatment)[1].
Synonyms	PC 786

Chemical Properties

Molecular Weight	715.84
Formula	C₄₁H₃₈FN₅O₄S
Cas No.	1902114-15-1
Smiles	O=C(NC=1C(F)=CC=CC1C)C=2SC=3C=4C=CC=CC4N(C(=O)C5=CC=C(C=C5)NC(=O)C6=CC(=CN=C6N7CC8(C7)CCOCC8)C)CCC3C2
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (167.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 4 mg/mL (5.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3970 mL	6.9848 mL	13.9696 mL	69.8480 mL
5 mM	0.2794 mL	1.3970 mL	2.7939 mL	13.9696 mL
10 mM	0.1397 mL	0.6985 mL	1.3970 mL	6.9848 mL
20 mM	0.0698 mL	0.3492 mL	0.6985 mL	3.4924 mL
50 mM	0.0279 mL	0.1397 mL	0.2794 mL	1.3970 mL
100 mM	0.0140 mL	0.0698 mL	0.1397 mL	0.6985 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc