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PC786
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Catalog No. T16439Cas No. 1902114-15-1
Alias PC 786
PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections, with antiviral activity against RSV-A (IC50=0.09-0.71 nM) and RSV-B (IC 50=1.3-50.6 nM), and the ability to inhibit RSV RNA-dependent RNA polymerase in HEp-2 cells ( RdRp).
PC786
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Purity: 99.26%
Catalog No. T16439Alias PC 786Cas No. 1902114-15-1
PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections, with antiviral activity against RSV-A (IC50=0.09-0.71 nM) and RSV-B (IC 50=1.3-50.6 nM), and the ability to inhibit RSV RNA-dependent RNA polymerase in HEp-2 cells ( RdRp).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,980 | 8-10 weeks | |
| 50 mg | $2,650 | 8-10 weeks | |
| 100 mg | $3,700 | 8-10 weeks |
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Purity:99.26%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections, with antiviral activity against RSV-A (IC50=0.09-0.71 nM) and RSV-B (IC 50=1.3-50.6 nM), and the ability to inhibit RSV RNA-dependent RNA polymerase in HEp-2 cells ( RdRp). |
| Targets&IC50 | RdRp (RSV, cell-free enzyme assay):14.11 μM, RdRp (RSV, minigenome assay in HEp-2 cells):0.5 nM, RSVA:<0.09–0.71 nM, RSVB:1.3–50.6 nM |
| In vitro | PC786 exhibits strong antiviral activity against RSV-A (IC₅₀: <0.09–0.71 nM) and RSV-B (IC₅₀: 1.3–50.6 nM) in HEp-2 cells, with no detectable cytotoxicity.[1] PCR analysis confirmed inhibition of RSV replication, and PC786 potently inhibited RSV RNA-dependent RNA polymerase (RdRp) activity in both a cell-free enzyme assay (IC₅₀: 2.1 nM) and a minigenome assay in HEp-2 cells (IC₅₀: 0.5 nM).[1] |
| In vivo | Treatment with PC786 (either intratracheal or intranasal; Once-daily on days-1 to 3), is found to inhibit viral loads in the lungs of RSV A2-infected BALB/c mice. The viral load is below the level of detection when the drug is given at 2 mg/mL (40 μg/mouse [approximately 1.6 mg/kg of body weight] for i.t. treatment, or 80 μg/mouse [approximately 3.2 mg/kg] for i.n. treatment)[1]. |
| Alias | PC 786 |
| Molecular Weight | 715.84 |
| Formula | C41H38FN5O4S |
| Cas No. | 1902114-15-1 |
| Smiles | O=C(NC=1C(F)=CC=CC1C)C=2SC=3C=4C=CC=CC4N(C(=O)C5=CC=C(C=C5)NC(=O)C6=CC(=CN=C6N7CC8(C7)CCOCC8)C)CCC3C2 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120.00 mg/mL (167.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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