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Phenyl-β-D-glucopyranoside

Name: Phenyl-β-D-glucopyranoside
Brand: TargetMol
SKU: TN6747
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6747Cas No. 1464-44-4

Alias PHENYL-B-D-GLUCOPYRANOSIDE

Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities.

Phenyl-β-D-glucopyranoside

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Purity: 98.95%

Catalog No. TN6747Alias PHENYL-B-D-GLUCOPYRANOSIDECas No. 1464-44-4

Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities.
In vitro	Phenyl-β-D-Glucopyranoside Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated RAW 264.7 Cells. Phenyl-β-D-glucopyranoside not only inhibited nitric oxide (NO) production but also significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) without inducing cytotoxicity. Phenyl-β-D-glucopyranoside also attenuated proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and other inflammation-related genes, such as IL-6 in a concentration-dependent manner. Furthermore, phenyl-β-D-glucopyranoside abolished increased adhesion, ninjurin 1 (Ninj1) expression, and matrix metalloproteinase (MMP) activity induced by endotoxin treatment. Finally, phenyl-β-D-glucopyranoside inhibited the nuclear translocation of nuclear factor-κB (NF-κB), which is one of the most important transcription factors involved in the inflammatory process.
Synonyms	PHENYL-B-D-GLUCOPYRANOSIDE

Chemical Properties

Molecular Weight	256.25
Formula	C₁₂H₁₆O₆
Cas No.	1464-44-4
Smiles	OC[C@H]1O[C@@H](Oc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.451 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: soluble

DMSO: 60 mg/mL (234.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9024 mL	19.5122 mL	39.0244 mL	195.1220 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL	39.0244 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL	19.5122 mL
20 mM	0.1951 mL	0.9756 mL	1.9512 mL	9.7561 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9024 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9512 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc