Anti-inflammatory agent 79

Name: Anti-inflammatory agent 79
Brand: TargetMol
SKU: T209687
Rating: 4.5 (1 reviews)

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Catalog No. T209687

Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), effectively blocking HIF-1 signaling and promoting the degradation of HIF-1α. It inhibits synovial invasion and migration, as well as angiogenesis. In mouse inflammation models, Anti-inflammatory agent 79 effectively reduces foot swelling and arthritis and lowers levels of inflammatory factors and angiogenesis in vivo.

Anti-inflammatory agent 79

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Catalog No. T209687

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Product Introduction

Bioactivity

Description	Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), effectively blocking HIF-1 signaling and promoting the degradation of HIF-1α. It inhibits synovial invasion and migration, as well as angiogenesis. In mouse inflammation models, Anti-inflammatory agent 79 effectively reduces foot swelling and arthritis and lowers levels of inflammatory factors and angiogenesis in vivo.
In vitro	Anti-inflammatory agent 79 (2.5-10 μM; 24 h) dose-dependently inhibits hypoxia-induced HIF-1α protein accumulation, reducing inflammatory responses. It suppresses cell invasiveness and enhances VHL-dependent HIF-1α degradation in human RA synovial cell lines.
In vivo	Administered as an anti-inflammatory agent, compound 79 (at doses of 30 mg/kg and 60 mg/kg; ip; every 2 days for a total of 16 days) reduced pathological damage in the ankle joints of rats with adjuvant-induced arthritis (AIA), decreased angiogenesis, and mitigated the inflammatory response.

Chemical Properties

Formula

C₂₁H₁₇NO₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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