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Myristoyl coenzyme A

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Catalog No. TXB-00073Cas No. 3130-72-1

Myristoyl coenzyme A lithium is a myristoylated form of coenzyme A (CoA). Myristoylation, an essential process in viruses, is typically regulated by N-myristoyltransferase (NMT), which is more active in colon epithelial tumors than in normal cells. The reduced form of coenzyme A (CoA) is a key regulator of NMT activity, whereas the oxidized form does not permit NMT to promote myristoylation. Myristoyl coenzyme A potentially inhibits demyristoylation, suggesting anticancer and antiviral mechanisms.

Myristoyl coenzyme A

Myristoyl coenzyme A

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Catalog No. TXB-00073Cas No. 3130-72-1
Myristoyl coenzyme A lithium is a myristoylated form of coenzyme A (CoA). Myristoylation, an essential process in viruses, is typically regulated by N-myristoyltransferase (NMT), which is more active in colon epithelial tumors than in normal cells. The reduced form of coenzyme A (CoA) is a key regulator of NMT activity, whereas the oxidized form does not permit NMT to promote myristoylation. Myristoyl coenzyme A potentially inhibits demyristoylation, suggesting anticancer and antiviral mechanisms.
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Product Introduction

Bioactivity
Description
Myristoyl coenzyme A lithium is a myristoylated form of coenzyme A (CoA). Myristoylation, an essential process in viruses, is typically regulated by N-myristoyltransferase (NMT), which is more active in colon epithelial tumors than in normal cells. The reduced form of coenzyme A (CoA) is a key regulator of NMT activity, whereas the oxidized form does not permit NMT to promote myristoylation. Myristoyl coenzyme A potentially inhibits demyristoylation, suggesting anticancer and antiviral mechanisms.
Chemical Properties
Molecular Weight977.89
FormulaC35H62N7O17P3S
Cas No.3130-72-1
SmilesO[C@H]1[C@@H](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCCCCCCCC)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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