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Bazedoxifene

Name: Bazedoxifene
Brand: TargetMol
SKU: T2544L
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2544LCas No. 198481-32-2

Alias TSE-424, TSE424

Bazedoxifene is a non-steroidal, orally active selective estrogen receptor modulator that exhibits activity against ERα and ERβ with IC50 values of 26 nM and 99 nM, respectively. Bazedoxifene also inhibits IL-6/GP130 protein interactions. Bazedoxifene is utilized in research on postmenopausal osteoporosis and pancreatic cancer, serving as a dual-purpose compound for hormonal and cytokine pathway investigations.

Bazedoxifene

🥰Excellent

Purity: 98.79%

Catalog No. T2544LAlias TSE-424, TSE424Cas No. 198481-32-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$140	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$318	In Stock	In Stock
100 mg	$497	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.79%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bazedoxifene is a non-steroidal, orally active selective estrogen receptor modulator that exhibits activity against ERα and ERβ with IC50 values of 26 nM and 99 nM, respectively. Bazedoxifene also inhibits IL-6/GP130 protein interactions. Bazedoxifene is utilized in research on postmenopausal osteoporosis and pancreatic cancer, serving as a dual-purpose compound for hormonal and cytokine pathway investigations.
Targets&IC50	ERα:26 nM, ERβ:99 nM
In vitro	In PANC-1, AsPC-1, and HPAF-II pancreatic carcinoma cells, Bazedoxifene (5-20μM, 2 hours) can inhibit IL-6 and IL-11-induced STAT3 phosphorylation in a dose-dependent manner [2].
In vivo	In the Capan-1 and HPAF-II pancreatic carcinoma xenograft models in mice, Bazedoxifene (5mg/kg/d, administered continuously for 18 days) significantly inhibited tumor growth and induced tumor cell apoptosis. The effect was more pronounced when used in combination with chemotherapeutic agents [2].
Synonyms	TSE-424, TSE424

Chemical Properties

Molecular Weight	470.61
Formula	C₃₀H₃₄N₂O₃
Cas No.	198481-32-2
Smiles	OC=1C=CC(=CC1)C2=C(C3=CC(O)=CC=C3N2CC4=CC=C(OCCN5CCCCCC5)C=C4)C
Relative Density.	1.19g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (169.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.01 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1249 mL	10.6245 mL	21.2490 mL	106.2451 mL
5 mM	0.4250 mL	2.1249 mL	4.2498 mL	21.2490 mL
10 mM	0.2125 mL	1.0625 mL	2.1249 mL	10.6245 mL
20 mM	0.1062 mL	0.5312 mL	1.0625 mL	5.3123 mL
50 mM	0.0425 mL	0.2125 mL	0.4250 mL	2.1249 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	1.0625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc