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Cysmethynil

Catalog No. T36082 CAS 851636-83-4

Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.

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Cysmethynil, CAS 851636-83-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 55.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 463.00
100 mg	In stock	$ 745.00
500 mg	In stock	$ 1,490.00

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Purity: 99%

Biological Description

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Description	Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
In vitro	Mouse embryonic fibroblasts grown in medium containing 8% serum were treated with concentrations of 15, 20, or 30 μM of Cysmethynil. The medium and drug were changed daily, and cell growth was monitored for 6 days,The results showed that treatment with Cysmethynil led to dose-dependent inhibition of growth in wild-type cells, while Icmt–/– cells were largely unaffected[1].
In vivo	Cysmethynil(20 mg/kg; intraperitoneal injection; three times per week; 2 weeks) used alone or in combination with Paclitaxel/Doxorubicin) significantly inhibits tumor growth. In a xenograft mouse model, Cysmethynil sensitizes cervical cancer cells to chemotherapy drugs[3].

Molecular Weight	376.53
Formula	C25H32N2O
CAS No.	851636-83-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 3.3 mg/mL

DMSO: 2 mg/mL (5.31 mM), Sonication is recommended.

Ethanol: 20 mg/mL

References and Literature

1. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41. 2. Wang M, et al. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem. 2008 Jul 4;283(27):18678-84. 3. Pan Q, et al. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway. Biomed Pharmacother. 2018 Mar;99:169-175. 4. Zhu C, et al. Targeting KRAS mutant cancers: from druggable therapy to drug resistance. Mol Cancer. 2022 Aug 4;21(1):159.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library

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Keywords

Cysmethynil 851636-83-4 Autophagy GPCR/G Protein MAPK Ras inhibitor inhibit

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