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Cysmethynil
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Catalog No. T36082Cas No. 851636-83-4
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
Cysmethynil
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Purity: 99%
Catalog No. T36082Cas No. 851636-83-4
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $39 | In Stock | In Stock | |
| 2 mg | $55 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $143 | In Stock | In Stock | |
| 25 mg | $289 | In Stock | In Stock | |
| 50 mg | $463 | In Stock | In Stock | |
| 100 mg | $745 | In Stock | In Stock | |
| 500 mg | $1,490 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cellular autophagy, and can be used for the study of solid tumours. |
| In vitro | Mouse embryonic fibroblasts grown in medium containing 8% serum were treated with concentrations of 15, 20, or 30 μM of Cysmethynil. The medium and drug were changed daily, and cell growth was monitored for 6 days,The results showed that treatment with Cysmethynil led to dose-dependent inhibition of growth in wild-type cells, while Icmt–/– cells were largely unaffected[1]. |
| In vivo | Cysmethynil(20 mg/kg; intraperitoneal injection; three times per week; 2 weeks) used alone or in combination with Paclitaxel/Doxorubicin) significantly inhibits tumor growth. In a xenograft mouse model, Cysmethynil sensitizes cervical cancer cells to chemotherapy drugs[3]. |
| Molecular Weight | 376.53 |
| Formula | C25H32N2O |
| Cas No. | 851636-83-4 |
| Smiles | O=C(N)CC1=CN(C2=CC=C(C=C21)C=3C=CC=C(C3)C)CCCCCCCC |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMF: 3.3 mg/mL (8.76 mM), Sonication is recommended. DMSO: 2 mg/mL (5.31 mM), Sonication is recommended. Ethanol: 20 mg/mL (53.12 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/DMF/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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