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SP-13786

Name: SP-13786
Brand: TargetMol
SKU: T7890
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7890Cas No. 1448440-52-5

Alias UAMC-1110

SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values of 3.2 nM and 1.8 μM, respectively.

SP-13786

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Purity: 99.96%

Catalog No. T7890Alias UAMC-1110Cas No. 1448440-52-5

SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values of 3.2 nM and 1.8 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$157	In Stock	In Stock
25 mg	$293	In Stock	In Stock
50 mg	$465	-	In Stock
100 mg	$745	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values of 3.2 nM and 1.8 μM, respectively.
Targets&IC50	PREP:1.8 μM, FAP:3.2 nM
In vivo	METHODS: SP-13786 (UAMC-1110) (20 mg/kg, orally, twice a day) was used to treat Panc02-SIY cell tumor xenograft mice, and its effect on tumors in the mice was observed. RESULTS Tumor-infiltrating macrophages were reduced during UAMC-1110 administration, and UAMC-1110 significantly increased tumor-infiltrating CD8 T cells, including effector subsets. [2]
Synonyms	UAMC-1110

Chemical Properties

Molecular Weight	344.32
Formula	C₁₇H₁₄F₂N₄O₂
Cas No.	1448440-52-5
Smiles	C(NCC(=O)N1[C@H](C#N)CC(F)(F)C1)(=O)C=2C3=C(N=CC2)C=CC=C3
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (290.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	145.2138 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	29.0428 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	14.5214 mL
20 mM	0.1452 mL	0.7261 mL	1.4521 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9043 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc