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N-pentadecanoyl-L-Homoserine lactone

Catalog No. T37745   CAS 182359-66-6

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. C15-HSL is a product of Y. pseudituberculosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
N-pentadecanoyl-L-Homoserine lactone, CAS 182359-66-6
Pack Size Availability Price/USD Quantity
5 mg Inquiry $ 43.00
10 mg Inquiry $ 85.00
25 mg Inquiry $ 207.00
50 mg Inquiry $ 372.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. C15-HSL is a product of Y. pseudituberculosis.
Molecular Weight 325.49
Formula C19H35NO3
CAS No. 182359-66-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

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DMF: 0.25 mg/mL

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Keywords

N-pentadecanoyl-L-Homoserine lactone 182359-66-6 N pentadecanoyl L Homoserine lactone NpentadecanoylLHomoserine lactone inhibitor inhibit

 

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