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CTLA-4 Protein, Cavia porcellus, Recombinant (His)

Catalog No. TMPJ-00640
Synonyms: Cytotoxic T-lymphocyte protein 4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4, CD152, CTLA-4

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CTLA-4 Protein, Cavia porcellus, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 116.00
50 μg 5 days $ 310.00
500 μg 5 days $ 1,390.00
1 mg 5 days $ 1,980.00
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Biological Description
Technical Params
Product Properties
Description Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Species Cavia porcellus
Expression System P. pastoris
Tag C-6His
Accession Number H0VUB1
Synonyms Cytotoxic T-lymphocyte protein 4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4, CD152, CTLA-4
Amino Acid Ala37-Asp161
Construction Recombinant Cavia Porcellus Cytotoxic T-lymphocyte Protein 4 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 18-40 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

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Keywords

CTLA-4 Protein, Cavia porcellus, Recombinant (His) Cytotoxic T-lymphocyte protein 4 CTLA4 Cytotoxic T-lymphocyte-associated antigen 4 CD-152 CD152 CTLA 4 CTLA-4 CD 152 recombinant recombinant-proteins proteins protein

 

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