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Croconazole
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Catalog No. T9878Cas No. 77175-51-0
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and
Croconazole
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Purity: 99.71%
Catalog No. T9878Cas No. 77175-51-0
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | In Stock | In Stock | |
| 5 mg | $98 | In Stock | In Stock | |
| 10 mg | $147 | In Stock | In Stock | |
| 25 mg | $239 | In Stock | In Stock | |
| 50 mg | $352 | In Stock | In Stock | |
| 100 mg | $523 | - | In Stock | |
| 500 mg | $1,170 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
Croconazole AI Summary
Croconazole exhibits broad-spectrum bioactivity, notably with antifungal properties, antiviral effects against SARS-CoV-2, antitrypanosomal activity, and inhibitory actions on various human enzymes and receptors. It demonstrates antifungal activity with minimum inhibitory concentrations (MIC) of 3.1 ug.mL-1 against both Candida albicans and Aspergillus fumigatus, and a stronger activity against Trichophyton asteroides with an MIC of 0.1 ug.mL-1. The compound shows potent antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity, achieving a 97.62% inhibition rate at a 10 uM concentration after 48 hours, and an IC50 value of 18920.0 nM in Caco-2 cells, displaying moderate selectivity with a CC50 value of 33000.0 nM. It partially inhibits the SARS-CoV-2 3CL-Pro protease by 14.39% at 20 µM and also presents a negative inhibition percentage in VERO-6 cell assays. Croconazole displays antitrypanosomal activity against Trypanosoma cruzi Y, with IC50 values of 24,000.0 nM for the bloodstream form and 16,000.0 nM for trypomastigotes. Additionally, it inhibits human HDAC6 enzyme activity. Beyond these activities, it binds to various human and rat receptors and channels including KCNH2, Cacna1c, and others, contributing to a complex pharmacological profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and |
| Molecular Weight | 310.78 |
| Formula | C18H15ClN2O |
| Cas No. | 77175-51-0 |
| Smiles | C(=C)(C1=C(OCC2=CC(Cl)=CC=C2)C=CC=C1)N3C=CN=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Acetonitrile: 1.55 mg/mL (4.99 mM), Sonication is recommended.  Methanol: 1.55 mg/mL (4.99 mM), Sonication is recommended. DMSO: 50 mg/mL (160.89 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Acetonitrile/Methanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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