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CASK Protein, Human, Recombinant (His & GST)

Catalog No. TMPY-04563
Synonyms: calcium/calmodulin-dependent serine protein kinase (MAGUK family), MRXSNA, CAMGUK, LIN2, CAGH39, hCASK, MICPCH, FGS4, TNRC8, CMG

CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.

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CASK Protein, Human, Recombinant (His & GST)
Pack Size Availability Price/USD Quantity
50 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
Species Human
Expression System Baculovirus Insect Cells
Tag His, GST
Accession Number O14936-4
Synonyms calcium/calmodulin-dependent serine protein kinase (MAGUK family), MRXSNA, CAMGUK, LIN2, CAGH39, hCASK, MICPCH, FGS4, TNRC8, CMG
Construction The Human CASK isoform 4 (O14936-4) (Ala 2-Tyr 898) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Protein Purity > 82 % as determined by SDS-PAGE
Molecular Weight 130 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2 contains oneguanylate kinase-like domain, twoL27 domains, onePDZ (DHR) domain, oneprotein kinase domain and oneSH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. CASK / LIN2 is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. CASK / LIN2 contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. It binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. CASK / LIN2 may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Defects in CASK are also the cause of FG syndrome type 4 which is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.

References and Literature

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Keywords

CASK Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent serine protein kinase (MAGUK family) FGS 4 MRXSNA FGS-4 CAMGUK TNRC 8 MAGUK family LIN 2 LIN2 CAGH39 hCASK MICPCH CAGH 39 LIN-2 TNRC-8 FGS4 CAGH-39 TNRC8 CMG recombinant recombinant-proteins proteins protein

 

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