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Phenylephrine

Name: Phenylephrine
Brand: TargetMol
SKU: T17310
Rating: 4.5 (1 reviews)

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Catalog No. T17310Cas No. 59-42-7

Alias L-Phenylephrine, (R)-(-)-Phenylephrine

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Phenylephrine

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Purity: 99.89%

Catalog No. T17310Alias L-Phenylephrine, (R)-(-)-PhenylephrineCas No. 59-42-7

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$42	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Targets&IC50	α1B-adrenoceptor:4.87 (pKi), α1A-adrenoceptor:4.70 (pKi), α1D-adrenoceptor:5.86 (pKi)
In vitro	Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
In vivo	Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].
Synonyms	L-Phenylephrine, (R)-(-)-Phenylephrine

Chemical Properties

Molecular Weight	167.21
Formula	C₉H₁₃NO₂
Cas No.	59-42-7
Smiles	CNC[C@H](O)c1cccc(O)c1
Relative Density.	1.1222 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (598.05 mM), Sonication is recommended.

H2O: 5 mg/mL (29.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (29.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9805 mL	29.9025 mL	59.8050 mL	299.0252 mL
5 mM	1.1961 mL	5.9805 mL	11.9610 mL	59.8050 mL
10 mM	0.5981 mL	2.9903 mL	5.9805 mL	29.9025 mL
20 mM	0.2990 mL	1.4951 mL	2.9903 mL	14.9513 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1196 mL	0.5981 mL	1.1961 mL	5.9805 mL
100 mM	0.0598 mL	0.2990 mL	0.5981 mL	2.9903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc