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Tetrahydrodeoxycorticosterone

Name: Tetrahydrodeoxycorticosterone
Brand: TargetMol
SKU: T37725
Rating: 4.5 (1 reviews)

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Catalog No. T37725Cas No. 567-03-3

Alias Tetrahydro-11-deoxycorticosterone, 21-Hydroxypregnanolone

Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.

Tetrahydrodeoxycorticosterone

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Purity: 99.40%

Catalog No. T37725Alias Tetrahydro-11-deoxycorticosterone, 21-HydroxypregnanoloneCas No. 567-03-3

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Purity:99.40%

Appearance:Solid

Color:White

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COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.
In vitro	At physiological concentrations, the endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) selectively enhances tonic currents mediated by αβδ receptors[1]. In the hippocampus, the reduction of neuronal excitability is observed with 10 nM Tetrahydrodeoxycorticosterone, achieved by augmenting tonic αβδ receptor currents. Notably, in thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, the same effect is not observed with 10 nM Tetrahydrodeoxycorticosterone[1].
In vivo	Sufficient concentrations of Tetrahydrodeoxycorticosterone (THDOC) in the brain tissue of mice with hepatic encephalopathy (HE), arising from toxic liver injury, can induce sedation in animals of the same species[2].
Synonyms	Tetrahydro-11-deoxycorticosterone, 21-Hydroxypregnanolone

Chemical Properties

Molecular Weight	334.49
Formula	C₂₁H₃₄O₃
Cas No.	567-03-3
Smiles	[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (269.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9896 mL	14.9481 mL	29.8963 mL	149.4813 mL
5 mM	0.5979 mL	2.9896 mL	5.9793 mL	29.8963 mL
10 mM	0.2990 mL	1.4948 mL	2.9896 mL	14.9481 mL
20 mM	0.1495 mL	0.7474 mL	1.4948 mL	7.4741 mL
50 mM	0.0598 mL	0.2990 mL	0.5979 mL	2.9896 mL
100 mM	0.0299 mL	0.1495 mL	0.2990 mL	1.4948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc