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Anti-inflammatory agent 49

Name: Anti-inflammatory agent 49
Brand: TargetMol
SKU: T83057
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T83057Cas No. 851471-44-8

Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.

Anti-inflammatory agent 49

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Purity: 99.74%

Catalog No. T83057Cas No. 851471-44-8

Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$695	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,480	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.
In vitro	In H9c2 cells, the anti-inflammatory agent 49 (2 µM; 16 hours) reduced the percentage of cells with fragmented mitochondria. The percentage of fragmented cells decreased from 22% (LPS + Veh) to 9% (LPS + SC9), compared to 4% in the absence of LPS[1].
In vivo	The anti-inflammatory agent 49 (10 mg/kg, every 8 hours for 72 hours) effectively treats endotoxemia induced by LPS in mice [1].

Chemical Properties

Molecular Weight	466.52
Formula	C₂₁H₂₂N₈O₃S
Cas No.	851471-44-8
Smiles	O=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (171.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1435 mL	10.7177 mL	21.4353 mL	107.1765 mL
5 mM	0.4287 mL	2.1435 mL	4.2871 mL	21.4353 mL
10 mM	0.2144 mL	1.0718 mL	2.1435 mL	10.7177 mL
20 mM	0.1072 mL	0.5359 mL	1.0718 mL	5.3588 mL
50 mM	0.0429 mL	0.2144 mL	0.4287 mL	2.1435 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc