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Siglec-15 Protein, Mouse, Recombinant (His)
(Synonyms: Siglec-15, Sialic acid-binding Ig-like lectin 15, CD33L3, CD33 antigen-like 3) Copy Product InfoSynonyms: Siglec-15, Sialic acid-binding Ig-like lectin 15, CD33L3, CD33 antigen-like 3
Catalog No. TMPJ-00225 Copy Product Info
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $55 | 35 days | 35 days | |
| 10 μg | $86 | 35 days | 35 days | |
| 20 μg | $137 | 35 days | 35 days | |
| 50 μg | $262 | 35 days | 35 days | |
| 100 μg | $488 | 35 days | 35 days | |
| 200 μg | $923 | 35 days | 35 days | |
| 500 μg | $2,150 | 35 days | 35 days | |
| 1 mg | $3,220 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Anti-Human Siglec15 mAb-mFc on AMQ Biosensor, can bind Mouse Siglec-15-His with an affinity constant of 0.33 nM as determined in BLI assay. (Regularly tested) |
| Description | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | A7E1W8 |
| Amino Acid | Arg24-Thr262 |
| Construction | Arg24-Thr262 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 150 mM NaCl, 5% Thehalose, 0.3% Chaps, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Siglec-15, Sialic acid-binding Ig-like lectin 15, CD33L3, CD33 antigen-like 3 |
| Research Background |
| Molecular Weight | 30-40 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: Siglec-15 Protein, Mouse, Recombinant (His) chemical structure | Siglec-15 Protein, Mouse, Recombinant (His) molecular weight
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