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5-(Biotinamido)pentylamine

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Catalog No. T38543Cas No. 115416-38-1

5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

5-(Biotinamido)pentylamine

5-(Biotinamido)pentylamine

🥰Excellent
Purity: 98.07%
Catalog No. T38543Cas No. 115416-38-1
5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$63In Stock
25 mg$98In Stock
50 mg$158In Stock
100 mg$247In Stock
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Batch Information

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Purity:98.07%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
In vitro
PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.
Chemical Properties
Molecular Weight328.47
FormulaC15H28N4O2S
Cas No.115416-38-1
SmilesC(CCCC(NCCCCCN)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.1.131 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (274 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.05 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0444 mL15.2221 mL30.4442 mL152.2209 mL
5 mM0.6089 mL3.0444 mL6.0888 mL30.4442 mL
10 mM0.3044 mL1.5222 mL3.0444 mL15.2221 mL
20 mM0.1522 mL0.7611 mL1.5222 mL7.6110 mL
50 mM0.0609 mL0.3044 mL0.6089 mL3.0444 mL
100 mM0.0304 mL0.1522 mL0.3044 mL1.5222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTACLinkerPROTAC LinkersPROTAC Linker5-(Biotinamido)pentylamine5(Biotinamido)pentylamine5 (Biotinamido)pentylamine
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