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LUF6000

Name: LUF6000
Brand: TargetMol
SKU: T15791
Rating: 4.5 (1 reviews)

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Catalog No. T15791Cas No. 890087-21-5

LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).

LUF6000

😃Good

Catalog No. T15791Cas No. 890087-21-5

LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).

Pack Size	Price	Availability
5 mg	$327	6-8 weeks
25 mg	$767	6-8 weeks
50 mg	$997	6-8 weeks
100 mg	$1,750	6-8 weeks
1 mL x 10 mM (in DMSO)	$358	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).

In vitro

LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist. LUF6000 exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher and was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. A3 adenosine receptor LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists.

Chemical Properties

Molecular Weight	411.33
Formula	C₂₂H₂₀Cl₂N₄
Cas No.	890087-21-5
Relative Density.	1.401 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14.29 mg/mL (34.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4311 mL	12.1557 mL	24.3114 mL	121.5569 mL
5 mM	0.4862 mL	2.4311 mL	4.8623 mL	24.3114 mL
10 mM	0.2431 mL	1.2156 mL	2.4311 mL	12.1557 mL
20 mM	0.1216 mL	0.6078 mL	1.2156 mL	6.0778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc