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Kynurenic acid sodium

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Catalog No. T22892Cas No. 2439-02-3
Alias Kynurenic acid sodium salt

Kynurenic acid sodium salt is an endogenous tryptophan metabolite that acts as a broad-spectrum antagonist targeting ionotropic glutamate receptors (NMDA), other glutamate receptors, and the α7 nicotinic acetylcholine receptor, while also functioning as a potent agonist for the G-protein coupled receptor GPR35/CXCR8.

Kynurenic acid sodium
Other Forms of Kynurenic acid sodium:

Kynurenic acid sodium

🥰Excellent
Purity: 99.47%
Catalog No. T22892Alias Kynurenic acid sodium saltCas No. 2439-02-3
Kynurenic acid sodium salt is an endogenous tryptophan metabolite that acts as a broad-spectrum antagonist targeting ionotropic glutamate receptors (NMDA), other glutamate receptors, and the α7 nicotinic acetylcholine receptor, while also functioning as a potent agonist for the G-protein coupled receptor GPR35/CXCR8.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$29-In Stock
50 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$40-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.47%
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Product Introduction

Bioactivity
Description
Kynurenic acid sodium salt is an endogenous tryptophan metabolite that acts as a broad-spectrum antagonist targeting ionotropic glutamate receptors (NMDA), other glutamate receptors, and the α7 nicotinic acetylcholine receptor, while also functioning as a potent agonist for the G-protein coupled receptor GPR35/CXCR8.
In vitro
Methods: Corneal epithelial cells and conjunctival epithelial cells were treated with Kynurenic acid sodium (1-100 μM, 24-48 hours), and cell viability was determined by MTT assay. Results: Kynurenic acid sodium caused a concentration-dependent decrease in the metabolic activity of these cells. [1]
SynonymsKynurenic acid sodium salt
Chemical Properties
Molecular Weight211.15
FormulaC10H6NNaO3
Cas No.2439-02-3
SmilesO=C(C1=CC(O)=C2C=CC=CC2=N1)[O-].[Na+]
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 40 mg/mL (189.44 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.7360 mL23.6798 mL47.3597 mL236.7985 mL
5 mM0.9472 mL4.7360 mL9.4719 mL47.3597 mL
10 mM0.4736 mL2.3680 mL4.7360 mL23.6798 mL
20 mM0.2368 mL1.1840 mL2.3680 mL11.8399 mL
50 mM0.0947 mL0.4736 mL0.9472 mL4.7360 mL
100 mM0.0474 mL0.2368 mL0.4736 mL2.3680 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

Kynurenic acid sodium
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