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Kynurenic acid sodium

Name: Kynurenic acid sodium
Brand: TargetMol
SKU: T22892
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22892Cas No. 2439-02-3

Alias Kynurenic acid sodium salt

Kynurenic acid sodium salt is an endogenous tryptophan metabolite that acts as a broad-spectrum antagonist targeting ionotropic glutamate receptors (NMDA), other glutamate receptors, and the α7 nicotinic acetylcholine receptor, while also functioning as a potent agonist for the G-protein coupled receptor GPR35/CXCR8.

Kynurenic acid sodium

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Purity: 99.47%

Catalog No. T22892Alias Kynurenic acid sodium saltCas No. 2439-02-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Kynurenic acid sodium salt is an endogenous tryptophan metabolite that acts as a broad-spectrum antagonist targeting ionotropic glutamate receptors (NMDA), other glutamate receptors, and the α7 nicotinic acetylcholine receptor, while also functioning as a potent agonist for the G-protein coupled receptor GPR35/CXCR8.
In vitro	Methods: Corneal epithelial cells and conjunctival epithelial cells were treated with Kynurenic acid sodium (1-100 μM, 24-48 hours), and cell viability was determined by MTT assay. Results: Kynurenic acid sodium caused a concentration-dependent decrease in the metabolic activity of these cells. [1]
Synonyms	Kynurenic acid sodium salt

Chemical Properties

Molecular Weight	211.15
Formula	C₁₀H₆NNaO₃
Cas No.	2439-02-3
Smiles	O=C(C1=CC(O)=C2C=CC=CC2=N1)[O-].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 40 mg/mL (189.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7360 mL	23.6798 mL	47.3597 mL	236.7985 mL
5 mM	0.9472 mL	4.7360 mL	9.4719 mL	47.3597 mL
10 mM	0.4736 mL	2.3680 mL	4.7360 mL	23.6798 mL
20 mM	0.2368 mL	1.1840 mL	2.3680 mL	11.8399 mL
50 mM	0.0947 mL	0.4736 mL	0.9472 mL	4.7360 mL
100 mM	0.0474 mL	0.2368 mL	0.4736 mL	2.3680 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc