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Chiniofon
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Catalog No. T9549Cas No. 547-91-1
Alias quiniophen, Loretin, Ferron, 8-hydroxy-7-iodo-5-quinolinesulfonate
Chiniofon (Ferron), a halogenated 8-hydroxyquinoline, is used as an antiamebic drug. This type of anti-amebic drug exerts an anti-amebic effect by inhibiting intestinal commensal bacteria and affects amoebic dysentery, but has no effect on extra-intestinal amoebic parasites.
Chiniofon
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Purity: 99.90%
Catalog No. T9549Alias quiniophen, Loretin, Ferron, 8-hydroxy-7-iodo-5-quinolinesulfonateCas No. 547-91-1
Chiniofon (Ferron), a halogenated 8-hydroxyquinoline, is used as an antiamebic drug. This type of anti-amebic drug exerts an anti-amebic effect by inhibiting intestinal commensal bacteria and affects amoebic dysentery, but has no effect on extra-intestinal amoebic parasites.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 g | $37 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.90%
Appearance:Solid
Color:Yellow
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Product Introduction
Chiniofon AI Summary
Chiniofon exhibits a range of bioactivities across multiple biological pathways and targets. It acts as an inhibitor in various assays, showcasing potency against Bacillus subtilis Sfp phosphopantetheinyl transferase, ROR gamma transcriptional activity, GCN5L2, Trypanosoma brucei phosphofructokinase, Histone Lysine Methyltransferase G9a, Vitamin D receptor, malarial parasite plastid delayed death pathways, firefly luciferase enzyme, Glutaminase (GLS), Trypanosoma brucei, human tyrosyl-DNA phosphodiesterase 1 (TDP1), Lassa Virus, and Ebola Virus. Additionally, it inhibits catechol-O-methyltransferase (COMT) in Sprague-Dawley rat liver, with an IC50 of 7079.46 nM. The compound also inhibits human HDAC6, though the inhibition is minimal (-2.71% with a commercial peptide substrate and -3.43% with a custom peptide substrate). Furthermore, Chiniofon demonstrates antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of 0.2325 in HRCE cells after 96 hours at an MOI of 0.4. These diverse inhibitory activities suggest its potential therapeutic implications in treating various diseases..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Chiniofon (Ferron), a halogenated 8-hydroxyquinoline, is used as an antiamebic drug. This type of anti-amebic drug exerts an anti-amebic effect by inhibiting intestinal commensal bacteria and affects amoebic dysentery, but has no effect on extra-intestinal amoebic parasites. |
| Synonyms | quiniophen, Loretin, Ferron, 8-hydroxy-7-iodo-5-quinolinesulfonate |
| Molecular Weight | 351.12 |
| Formula | C9H6INO4S |
| Cas No. | 547-91-1 |
| Smiles | OC1=C(I)C=C(C2=CC=CN=C12)S(O)(=O)=O |
| Relative Density. | 2.193g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 3.52 mg/mL (10.03 mM), Sonication is recommended.  H2O: 2 mg/mL (5.7 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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