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Trimetazidine
🥰Excellent
Catalog No. T22444Cas No. 5011-34-7
Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects.
Trimetazidine
🥰Excellent
Purity: 99.9%
Catalog No. T22444Cas No. 5011-34-7
Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $34 | In Stock | |
| 10 mg | $46 | In Stock | |
| 25 mg | $60 | In Stock | |
| 50 mg | $74 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.9%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects. |
| Targets&IC50 | Long chain 3-ketoyl coenzyme A thiolase:75 nM |
| In vitro | Methods: Mouse C2C12 myoblasts were treated with Trimetazidine (50–200 μM, 6 hours), and cell viability was measured using CCK-8 reagent. Result: Trimetazidine at concentrations of 150 μM and 200 μM significantly reversed dexamethasone-induced cell death.[1] |
| In vivo | Methods: Trimetazidine (5 mg/kg, administered intraperitoneally for 12 consecutive days) was injected into C26 colon carcinoma mice to study the "exercise-mimicking" effects of trimetazidine in a cancer cachexia mouse model. Results: Trimetazidine enhanced metabolic adaptive mechanisms in cancer cachexia mice by mimicking the effects of exercise, including increased grip strength, elevated proportion of slow muscle fibers, upregulated PGC1α expression, and enhanced mitochondrial biogenesis and oxidative metabolism. [2] |
| Molecular Weight | 266.34 |
| Formula | C14H22N2O3 |
| Cas No. | 5011-34-7 |
| Smiles | COc1ccc(CN2CCNCC2)c(OC)c1OC |
| Relative Density. | 1.092 g/cm3 |
| Color | White |
| Appearance | Viscous |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 85.00 mg/mL (319.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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