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Tilogotamab
(Synonyms: Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029) Copy Product Info
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Synonyms: Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029
Catalog No. T80984 Copy Product Info
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Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
Cas No. 2109731-10-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | In Stock | In Stock | |
| 5 mg | $463 | - | In Stock | |
| 10 mg | $737 | - | In Stock | |
| 25 mg | $1,360 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98% (SDS-PAGE); 99.45% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM). |
| In vitro | Tilogotamab (20 μg/mL,24h) induced strong cytotoxicity in primary multiple myeloma (MM) cells. [1] |
| In vivo | Tilogotamab at a concentration of 20 μg/mL for 24 hours exhibits potent cytotoxicity against primary MM cells [1]. Tilogotamab is a mixture of two non-competitive DR5-specific monoclonal immunoglobulin G1 (IgG1) antibodies, each featuring an E430G mutation in the Fc domain. This mutation enhances Fc-Fc interactions, leading to antibody hexamerization and subsequent FcγR-independent clustering of DR5 molecules [1]. |
| Synonyms | Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF10B/TRAILR2/CD262 |
| Molecular Weight | 144.88 kDa |
| Cas No. | 2109731-10-2 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Tilogotamab chemical structure | Tilogotamab in vivo | Tilogotamab in vitro | Tilogotamab molecular weight
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