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Tilogotamab
🥰Excellent
Catalog No. T80984Cas No. 2109731-10-2
Alias Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029
Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
Tilogotamab
Tilogotamab
🥰Excellent
Purity: 95%
Catalog No. T80984Alias Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029Cas No. 2109731-10-2
Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $568 | - | In Stock | |
| 10 mg | $910 | - | In Stock | |
| 25 mg | $1,370 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM). |
| In vitro | Tilogotamab (20 μg/mL,24h) induced strong cytotoxicity in primary multiple myeloma (MM) cells. [1] |
| In vivo | Tilogotamab at a concentration of 20 μg/mL for 24 hours exhibits potent cytotoxicity against primary MM cells [1]. Tilogotamab is a mixture of two non-competitive DR5-specific monoclonal immunoglobulin G1 (IgG1) antibodies, each featuring an E430G mutation in the Fc domain. This mutation enhances Fc-Fc interactions, leading to antibody hexamerization and subsequent FcγR-independent clustering of DR5 molecules [1]. |
| Synonyms | Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Host Species | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 2109731-10-2 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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