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Tetrahydrocortisol

Name: Tetrahydrocortisol
Brand: TargetMol
SKU: T17057
Rating: 4.5 (1 reviews)

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Catalog No. T17057Cas No. 53-02-1

Alias Tetrahydrohydrocortisone

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Tetrahydrocortisol

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Catalog No. T17057Alias TetrahydrohydrocortisoneCas No. 53-02-1

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	Inquiry	Inquiry
5 mg	$268	Inquiry	Inquiry
10 mg	$498	Inquiry	Inquiry
25 mg	$1,040	Inquiry	Inquiry
50 mg	Inquiry	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$320	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.
Targets&IC50	actin network formation (human trabecular meshwork cells):5.7 × 10⁻⁷ M
In vitro	Tetrahydrocortisol dose-dependently inhibited Dexamethasone (10⁻⁷ M)-induced actin network formation in human trabecular meshwork cells (IC₅₀ = 5.7 × 10⁻⁷ M; up to 14 days), and partially reversed microtubule changes, indicating cytoskeletal modulation[1].
Synonyms	Tetrahydrohydrocortisone

Chemical Properties

Molecular Weight	366.49
Formula	C₂₁H₃₄O₅
Cas No.	53-02-1
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Relative Density.	0.889 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (109.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7286 mL	13.6429 mL	27.2859 mL	136.4294 mL
5 mM	0.5457 mL	2.7286 mL	5.4572 mL	27.2859 mL
10 mM	0.2729 mL	1.3643 mL	2.7286 mL	13.6429 mL
20 mM	0.1364 mL	0.6821 mL	1.3643 mL	6.8215 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7286 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc