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Tetrahydrocortisol

Name: Tetrahydrocortisol
Brand: TargetMol
SKU: T17057
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17057Cas No. 53-02-1

Alias Tetrahydrohydrocortisone

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Tetrahydrocortisol

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Purity: 97.01%

Catalog No. T17057Alias TetrahydrohydrocortisoneCas No. 53-02-1

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$80	Inquiry	Inquiry
10 mg	$147	Inquiry	Inquiry
25 mg	$329	Inquiry	Inquiry
50 mg	$489	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$88	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.01%

Appearance:Solid

Color:White

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COA MS HNMR

Product Introduction

Bioactivity

Description	Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.
Targets&IC50	actin network formation (human trabecular meshwork cells):5.7 × 10⁻⁷ M
In vitro	Tetrahydrocortisol dose-dependently inhibited Dexamethasone (10⁻⁷ M)-induced actin network formation in human trabecular meshwork cells (IC₅₀ = 5.7 × 10⁻⁷ M; up to 14 days), and partially reversed microtubule changes, indicating cytoskeletal modulation[1].
Synonyms	Tetrahydrohydrocortisone

Chemical Properties

Molecular Weight	366.49
Formula	C₂₁H₃₄O₅
Cas No.	53-02-1
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Relative Density.	0.889 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (109.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7286 mL	13.6429 mL	27.2859 mL	136.4294 mL
5 mM	0.5457 mL	2.7286 mL	5.4572 mL	27.2859 mL
10 mM	0.2729 mL	1.3643 mL	2.7286 mL	13.6429 mL
20 mM	0.1364 mL	0.6821 mL	1.3643 mL	6.8215 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7286 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc