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2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

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Catalog No. T83811
Alias 2'(3')-ANT-ATP

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and its isomer 3'-ANT-ATP are fluorescent derivatives of ATP that spontaneously isomerize. Emitting a maximum light of 428 nm when excited at 330 nm in water, 2'(3')-ANT-ATP specifically inhibits several types of adenylyl cyclase (AC) including mammalian AC1, AC2, and AC5 with inhibition constants (Kis) of 130, 640, and 120 nM, respectively. It also inhibits Bordetella pertussis AC toxin CyaA with Kis of 1.3 µM (in the presence of manganese) and 20 µM (in the presence of magnesium), Bacillus anthracis AC toxin edema factor with Kis of 0.44 µM (with manganese) and 5.15 µM (with magnesium), and Escherichia coli recombinase A (RecA) with a Ki of 6.3 µM.

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

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Catalog No. T83811Alias 2'(3')-ANT-ATP
2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and its isomer 3'-ANT-ATP are fluorescent derivatives of ATP that spontaneously isomerize. Emitting a maximum light of 428 nm when excited at 330 nm in water, 2'(3')-ANT-ATP specifically inhibits several types of adenylyl cyclase (AC) including mammalian AC1, AC2, and AC5 with inhibition constants (Kis) of 130, 640, and 120 nM, respectively. It also inhibits Bordetella pertussis AC toxin CyaA with Kis of 1.3 µM (in the presence of manganese) and 20 µM (in the presence of magnesium), Bacillus anthracis AC toxin edema factor with Kis of 0.44 µM (with manganese) and 5.15 µM (with magnesium), and Escherichia coli recombinase A (RecA) with a Ki of 6.3 µM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mgInquiry3-6 months3-6 months
50 mgInquiry3-6 months3-6 months
100 mgInquiry3-6 months3-6 months
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Product Introduction

Bioactivity
Description
2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and its isomer 3'-ANT-ATP are fluorescent derivatives of ATP that spontaneously isomerize. Emitting a maximum light of 428 nm when excited at 330 nm in water, 2'(3')-ANT-ATP specifically inhibits several types of adenylyl cyclase (AC) including mammalian AC1, AC2, and AC5 with inhibition constants (Kis) of 130, 640, and 120 nM, respectively. It also inhibits Bordetella pertussis AC toxin CyaA with Kis of 1.3 µM (in the presence of manganese) and 20 µM (in the presence of magnesium), Bacillus anthracis AC toxin edema factor with Kis of 0.44 µM (with manganese) and 5.15 µM (with magnesium), and Escherichia coli recombinase A (RecA) with a Ki of 6.3 µM.
Synonyms2'(3')-ANT-ATP
Chemical Properties
Molecular Weight714.23
FormulaC17H17N6O14P3.4Na
SmilesO[C@@H]1[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1OC(C4=C(N)C=CC=C4)=O.O[C@@H]5[C@H](OC(C6=C(N)C=CC=C6)=O)[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@H]5N7C8=NC=NC(N)=C8N=C7.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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