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4-Acetamidobenzenesulfonamide

Name: 4-Acetamidobenzenesulfonamide
Brand: TargetMol
SKU: T8627
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8627Cas No. 121-61-9

4-Acetamidobenzenesulfonamide used in proteomics research and is an anti-infective agent

4-Acetamidobenzenesulfonamide

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Purity: 99.86%

Catalog No. T8627Cas No. 121-61-9

4-Acetamidobenzenesulfonamide used in proteomics research and is an anti-infective agent

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$31	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

4-Acetamidobenzenesulfonamide AI Summary

4-Acetamidobenzenesulfonamide exhibits a variety of biological activities across different targets. It shows in vitro inhibitory activity against the H1N9 strain of Influenza neuraminidase at a concentration of 7 mM, but with an inhibition percentage of 0.0%, suggesting no effective inhibition at this concentration. The compound also inhibits various isoforms of carbonic anhydrase, including human cytosolic isozymes I and II, bovine membrane-bound isozyme IV, and murine mitochondrial isozyme V, with Ki values ranging from 212.0 nM to 21,400.0 nM. It demonstrates significant selectivity towards human carbonic anhydrase II over mouse carbonic anhydrase V with a selectivity ratio of 1.16. Additionally, it inhibits human carbonic anhydrase I, II, IX, and XII with Ki values of 21,400.0 nM, 246.0 nM, 135.0 nM, and 49.0 nM, respectively. 4-Acetamidobenzenesulfonamide also shows inhibitory effects on human AQP4b-mediated water transport in Xenopus oocytes at 20 µM with an inhibition of 23.0%, and it inhibits AQP4 in rat FRT cells with a permeability of 0.0129 cm/s at 100 µM concentration. Lastly, it demonstrates antibacterial activity against Enterococcus faecium HM965, with an MIC greater than 64.0 µg/mL, indicating moderate to low effectiveness..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

4-Acetamidobenzenesulfonamide used in proteomics research and is an anti-infective agent

Chemical Properties

Molecular Weight	214.24
Formula	C₈H₁₀N₂O₃S
Cas No.	121-61-9
Smiles	CC(=O)NC1=CC=C(C=C1)S(N)(=O)=O
Relative Density.	1.384 g/cm3. Temperature:25 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (116.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6677 mL	23.3383 mL	46.6766 mL	233.3831 mL
5 mM	0.9335 mL	4.6677 mL	9.3353 mL	46.6766 mL
10 mM	0.4668 mL	2.3338 mL	4.6677 mL	23.3383 mL
20 mM	0.2334 mL	1.1669 mL	2.3338 mL	11.6692 mL
50 mM	0.0934 mL	0.4668 mL	0.9335 mL	4.6677 mL
100 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3338 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc