Shopping Cart
- Remove All
Your shopping cart is currently empty
xStAx-VHLL TFA
🥰Excellent
Catalog No. T36275L
xStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer.
xStAx-VHLL TFA
xStAx-VHLL TFA
🥰Excellent
Purity: 99.84%
Catalog No. T36275L
xStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $94 | In Stock | |
| 5 mg | $242 | In Stock | |
| 10 mg | $389 | In Stock | |
| 25 mg | $642 | In Stock | |
| 50 mg | $883 | In Stock | |
| 100 mg | $1,190 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.84%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | xStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer. |
| In vitro | Both 10 μM MSAB and 50 μM xStAx-VHLL TFA decreased β-catenin protein to a comparable level after 24 h treatment in HEK293T, HCT116, and SW480 cells. In LoVo cells, only xStAx-VHLL TFA was able to reduce the β-catenin protein level, while MSAB had no effect. [1] |
| In vivo | Because APCmin/+ mice can develop intestinal tumors around 10 weeks-old, the 11 weeks-old APCmin/+ mice were intraperitoneally injected with 30 mg/kg vehicle DMSO or xStAx-VHLL TFA at every other day for 14 days. The xStAx-VHLL TFA reduced tumor number compared with that of 11 weeks-old mice before treatment (day 0) or with vehicle DMSO treatment. [1] |
| Molecular Weight | 3231.89 (free base) |
| Formula | C154H244N48O29.xC2HF3O2 |
| Color | White |
| Appearance | Solid |
| Sequence | Ac-Arg-Arg-Trp-Pro-Arg-{S5}-Ile-Leu-Asp-{S5}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2 |
| Sequence Short | Ac-RRWPR{S5}ILD{S5}HVRRVWR-{Ahx}-ALAPYIP-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 80 mg/mL, Sonication is recommended. H2O: 80 mg/mL, Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy xStAx-VHLL TFA | purchase xStAx-VHLL TFA | xStAx-VHLL TFA cost | order xStAx-VHLL TFA | xStAx-VHLL TFA in vivo | xStAx-VHLL TFA in vitro | xStAx-VHLL TFA formula | xStAx-VHLL TFA molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.