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OVA (329-337)

Name: OVA (329-337)
Brand: TargetMol
SKU: T40360
Rating: 4.5 (1 reviews)

(Synonyms: MS-31727, DA-66405, (4S)-5-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxyethyl]amino]-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid) Copy Product Info

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Synonyms: MS-31727, DA-66405, (4S)-5-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxyethyl]amino]-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

Catalog No. T40360 Copy Product Info

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OVA (329-337)(DA-66405) is a 9-amino acid core epitope located at the C-terminus of the OVA peptide segment (positions 329 to 337). OVA (329-337) can be effectively recognized by immune cells and activate T cell responses.

Cas No. 276889-40-8

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	OVA (329-337)(DA-66405) is a 9-amino acid core epitope located at the C-terminus of the OVA peptide segment (positions 329 to 337). OVA (329-337) can be effectively recognized by immune cells and activate T cell responses.
Targets & IC50	DO11.10:25 μM, OT-II:30 μM
In vitro	Method: Splenocytes from DO11.10 and OT-II mice were stimulated with OVA(329-339) peptide (0.1-1 μM) under in vitro conditions to establish T cell lines. Using N-terminally and C-terminally truncated peptides as well as single amino acid substitution peptides (0.002-100 μM), T cell proliferation was measured by ³H-thymidine incorporation assay. Result: OVA(329-339) induced half-maximal proliferation in DO11.10 and OT-II cells at concentrations of 25 μM and 30 μM, respectively [1].
In vivo	Method: BALB/c mice were subcutaneously immunized with OVA protein (10 μg, CFA adjuvant). Nine days later, T cells from draining lymph nodes were collected for clonal analysis. Result: Following in vivo immunization with 10 μg of OVA protein, OVA(329-337) was recognized as a T cell epitope, and OVA323-339 became a hotspot of the T cell response due to the presence of multiple overlapping epitopes [1].
Synonyms	MS-31727, DA-66405, (4S)-5-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxyethyl]amino]-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

Chemical Properties

Molecular Weight	924.97
Formula	C₃₈H₆₀N₁₂O₁₅
Cas No.	276889-40-8
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O
Relative Density.	1.363 g/cm3 (Predicted)
Sequence	Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala
Sequence Short	AAHAEINEA

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble)

H2O: 1.46 mg/mL (1.58 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.0811 mL	5.4056 mL	10.8112 mL	54.0558 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OVA (329337)OVA (329 337)OVA

Related Tags: OVA (329-337) chemical structure | OVA (329-337) in vivo | OVA (329-337) in vitro | OVA (329-337) formula | OVA (329-337) molecular weight