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Crobenetine

Name: Crobenetine
Brand: TargetMol
SKU: T69795
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T69795Cas No. 221019-25-6

Alias Crobenetine Free Base, BIII 890

Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.

Crobenetine

🥰Excellent

Purity: 98.99%

Catalog No. T69795Alias Crobenetine Free Base, BIII 890Cas No. 221019-25-6

Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.

Pack Size	Price	Availability
1 mg	$310	In Stock
5 mg	$757	In Stock
10 mg	$1,060	In Stock
25 mg	$1,580	In Stock
50 mg	$2,130	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.99%

ee:98.50%

Resource Download

COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.
Synonyms	Crobenetine Free Base, BIII 890

Chemical Properties

Molecular Weight	379.54
Formula	C₂₅H₃₃NO₂
Cas No.	221019-25-6
Smiles	C[C@]12C=3C(C[C@](C1(C)C)(N(C[C@@H](OCC4=CC=CC=C4)C)CC2)[H])=C(O)C=CC3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (131.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6348 mL	13.1738 mL	26.3477 mL	131.7384 mL
5 mM	0.5270 mL	2.6348 mL	5.2695 mL	26.3477 mL
10 mM	0.2635 mL	1.3174 mL	2.6348 mL	13.1738 mL
20 mM	0.1317 mL	0.6587 mL	1.3174 mL	6.5869 mL
50 mM	0.0527 mL	0.2635 mL	0.5270 mL	2.6348 mL
100 mM	0.0263 mL	0.1317 mL	0.2635 mL	1.3174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc