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PSB-603

Name: PSB-603
Brand: TargetMol
SKU: T23203
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23203Cas No. 1092351-10-4

Alias PSB 603

PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.

PSB-603

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Purity: 97.14%

Catalog No. T23203Alias PSB 603Cas No. 1092351-10-4

PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$591	In Stock	In Stock
100 mg	$987	8-10 weeks	8-10 weeks
200 mg	$1,330	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.14%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
In vitro	In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold[2]. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors[4].
In vivo	PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes[3].
Synonyms	PSB 603

Chemical Properties

Molecular Weight	529.01
Formula	C₂₄H₂₅ClN₆O₄S
Cas No.	1092351-10-4
Smiles	CCCn1c(=O)[nH]c2[nH]c(nc2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)cc1
Relative Density.	1.430 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 23.9 mg/mL (45.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8903 mL	9.4516 mL	18.9032 mL	94.5162 mL
5 mM	0.3781 mL	1.8903 mL	3.7806 mL	18.9032 mL
10 mM	0.1890 mL	0.9452 mL	1.8903 mL	9.4516 mL
20 mM	0.0945 mL	0.4726 mL	0.9452 mL	4.7258 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc