Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $437 | In Stock | |
10 mg | $646 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,380 | In Stock | |
100 mg | $1,860 | In Stock | |
500 mg | $3,720 | In Stock |
Description | PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin. |
In vitro | Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1]. |
Alias | PRLX-93936 hcl(903499-49-0 Free base) |
Molecular Weight | 437.37 |
Formula | C21H26Cl2N4O2 |
Cas No. | 1094210-96-4 |
Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 50.00 mg/mL |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.