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PRLX-93936 HCL

Name: PRLX-93936 HCL
Brand: TargetMol
SKU: T36404L
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36404LCas No. 1094210-96-4

Alias PRLX-93936 hcl(903499-49-0 Free base)

PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

PRLX-93936 HCL

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Purity: 99.94%

Catalog No. T36404LAlias PRLX-93936 hcl(903499-49-0 Free base)Cas No. 1094210-96-4

PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$562	In Stock	In Stock
25 mg	$889	In Stock	In Stock
50 mg	$1,190	In Stock	In Stock
100 mg	$1,590	-	In Stock
200 mg	$2,170	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.94%

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COA LCMS

Product Introduction

Bioactivity

Description	PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
In vitro	Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1].
Synonyms	PRLX-93936 hcl(903499-49-0 Free base)

Chemical Properties

Molecular Weight	437.37
Formula	C₂₁H₂₆Cl₂N₄O₂
Cas No.	1094210-96-4
Smiles	Cl.Cl.CCOc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2864 mL	11.4320 mL	22.8639 mL	114.3197 mL
5 mM	0.4573 mL	2.2864 mL	4.5728 mL	22.8639 mL
10 mM	0.2286 mL	1.1432 mL	2.2864 mL	11.4320 mL
20 mM	0.1143 mL	0.5716 mL	1.1432 mL	5.7160 mL
50 mM	0.0457 mL	0.2286 mL	0.4573 mL	2.2864 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1432 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc