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PRLX-93936 HCL

PRLX-93936 HCL
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
Catalog No. T36404LCas No. 1094210-96-4
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Purity:100%
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PRLX-93936 HCL

Catalog No. T36404LCas No. 1094210-96-4

PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
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Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$437In Stock
10 mg$646In Stock
25 mg$987In Stock
50 mg$1,380In Stock
100 mg$1,860In Stock
500 mg$3,720In Stock
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Product Introduction

Bioactivity
Description
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
In vitro
Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1].
AliasPRLX-93936 hcl(903499-49-0 Free base)
Chemical Properties
Molecular Weight437.37
FormulaC21H26Cl2N4O2
Cas No.1094210-96-4
Storage & Solubility Information
Storagekeep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50.00 mg/mL

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