keep away from moisture,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 437.00 | |
10 mg | In stock | $ 646.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 | |
100 mg | In stock | $ 1,860.00 | |
500 mg | In stock | $ 3,720.00 |
Description | PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin. |
In vitro | Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1]. |
Synonyms | PRLX-93936 hcl(903499-49-0 Free base) |
Molecular Weight | 437.37 |
Formula | C21H26Cl2N4O2 |
CAS No. | 1094210-96-4 |
keep away from moisture,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50.00mg/ml
You can also refer to dose conversion for different animals. More
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PRLX-93936 HCL 1094210-96-4 Apoptosis Immunology/Inflammation Metabolism NF-Κb Ferroptosis Reactive Oxygen Species PRLX93936 HCL PRLX 93936 HCL PRLX-93936 hcl(903499-49-0 Free base) inhibitor inhibit