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PRLX-93936 HCL

Catalog No. T36404L   CAS 1094210-96-4
Synonyms: PRLX-93936 hcl(903499-49-0 Free base)

PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PRLX-93936 HCL Chemical Structure
PRLX-93936 HCL, CAS 1094210-96-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 195.00
5 mg In stock $ 437.00
10 mg In stock $ 646.00
25 mg In stock $ 987.00
50 mg In stock $ 1,380.00
100 mg In stock $ 1,860.00
500 mg In stock $ 3,720.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
In vitro Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1].
Synonyms PRLX-93936 hcl(903499-49-0 Free base)
Molecular Weight 437.37
Formula C21H26Cl2N4O2
CAS No. 1094210-96-4

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50.00mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Liang Z, et al. Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells. Biochem Biophys Res Commun. 2021 Sep 10;569:79-85.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Mitochondria-Targeted Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Clinical Compound Library Bioactive Compound Library Anti-Lung Cancer Compound Library NF-κB Signaling Compound Library

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Keywords

PRLX-93936 HCL 1094210-96-4 Apoptosis Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Ferroptosis PRLX93936 HCL PRLX 93936 HCL PRLX-93936 hcl(903499-49-0 Free base) inhibitor inhibit

 

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