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3-hydroxy-3-phenylpentanamide

Name: 3-hydroxy-3-phenylpentanamide
Brand: TargetMol
SKU: T50100
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50100Cas No. 131802-69-2

3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In psychiatry, it has been studied as a potential treatment for anxiety, depression and addiction. In oncology, it has been shown to have antitumor activity by inducing apoptosis and inhibiting tumor growth.

3-hydroxy-3-phenylpentanamide

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Purity: 98.42%

Catalog No. T50100Cas No. 131802-69-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$333	In Stock	In Stock
25 mg	$538	In Stock	In Stock
50 mg	$738	In Stock	In Stock
100 mg	$990	In Stock	In Stock
200 mg	$1,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.42%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

3-hydroxy-3-phenylpentanamide AI Summary

3-hydroxy-3-phenylpentanamide exhibits diverse bioactivities, with notable antiviral properties demonstrated by its ability to inhibit SARS-CoV-2 induced cytotoxicity in Caco-2 cells (inhibitory effect of 29.94% at 10 µM after 48 hours) and VERO-6 cells (inhibition of -0.1% at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus). Furthermore, the compound inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 15.81% at 20 µM, suggesting potential as a protease inhibitor. In antibacterial assays, 3-hydroxy-3-phenylpentanamide shows inhibition rates against Pseudomonas aeruginosa ATCC 27853 (1.83%) and Acinetobacter baumannii ATCC 19606 (11.78%), but has a negative inhibition rate against Pseudomonas aeruginosa PAO397 (-9.36%). Additionally, the compound exhibits bioactivity against Mycobacterium tuberculosis and minor inhibition of an enzyme related to Toxoplasma. It also shows varying inhibition on the human HDAC6 enzyme with 21.65% inhibition on a commercial peptide substrate and -6.56% on a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	193.24
Formula	C₁₁H₁₅NO₂
Cas No.	131802-69-2
Smiles	C(CC(N)=O)(CC)(O)C1=CC=CC=C1
Relative Density.	1.13g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (258.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL	258.7456 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL	51.7491 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL	25.8746 mL
20 mM	0.2587 mL	1.2937 mL	2.5875 mL	12.9373 mL
50 mM	0.1035 mL	0.5175 mL	1.0350 mL	5.1749 mL
100 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5875 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc