Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 112.00 | |
5 mg | In stock | $ 260.00 | |
10 mg | In stock | $ 390.00 | |
25 mg | In stock | $ 653.00 | |
50 mg | In stock | $ 928.00 | |
100 mg | In stock | $ 1,260.00 | |
500 mg | In stock | $ 2,530.00 |
Description | Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals. |
In vivo | Fezolamine (100-450 mg/day; oral; 6 weeks; 42 patients) significant improvement relative to the patient's prestudy state was observed after 2 weeks in both patient and physician-rating scales. Fifty-five percent of patients improved their Hamilton Psychiatric Rating Scale for Depression (HAM-D) scores by more than 50%. The median dose associated with a clinically significant response was 245 mg/day. Five of the 6 patients who dropped out did so because of gastrointestinal adverse effects. The most common adverse effects were nausea (36%), headache (29%), constipation (26%), and dry mouth (24%).[1] |
Molecular Weight | 305.42 |
Formula | C20H23N3 |
CAS No. | 80410-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Fezolamine 80410-36-2 Neuroscience Norepinephrine inhibitor inhibit