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AM-8735

Name: AM-8735
Brand: TargetMol
SKU: T14203
Rating: 4.5 (1 reviews)

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Catalog No. T14203Cas No. 1429386-01-5

AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).

AM-8735

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Catalog No. T14203Cas No. 1429386-01-5

AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	8-10 weeks	8-10 weeks
50 mg	$2,380	8-10 weeks	8-10 weeks
100 mg	$3,100	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
Targets&IC50	MDM2:25 nM
In vitro	AM-8735 exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM).
In vivo	AM-8735 exhibits potent antitumor properties in the SJSA-1 osteosarcoma xenograft model, achieving an effective dose (ED50) of 41 mg/kg[1]. Additionally, AM-8735 significantly induces p21 mRNA expression in a time- and concentration-dependent manner within SJSA-1 osteosarcoma tumors, as demonstrated through in vivo pharmacodynamic assays.

Chemical Properties

Molecular Weight	568.51
Formula	C₂₇H₃₁Cl₂NO₆S
Cas No.	1429386-01-5
Smiles	[C@H](CS(C(C)(C)C)(=O)=O)(N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)C2=CC(Cl)=CC=C2)C3=CC=C(Cl)C=C3)[C@H]4CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc