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Alclofenac

Name: Alclofenac
Brand: TargetMol
SKU: T29842
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29842Cas No. 22131-79-9

Alias W-7320, W7320, W 7320, MY 101, BRN 2116510

Alclofenac (W-7320) has a significant effect on the acute phase protein response and the degree of L-tryptophan binding to plasma protein and can be used in the treatment of patients with chronic rheumatism.

Alclofenac

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Purity: 99.89%

Catalog No. T29842Alias W-7320, W7320, W 7320, MY 101, BRN 2116510Cas No. 22131-79-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$99	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Alclofenac AI Summary

Alclofenac is a bioactive small molecule with diverse biological effects. It exhibits intrinsic aqueous solubility with a logS0 of -3.13 at pH 10 as determined by the shake-flask method. In bioassays, it acts as an inhibitor of the GCN5L2 enzyme, showing a potency of 19952.6 nM. Additionally, it has been tested for drug-induced liver injury (DILI) and shows a significant risk, with a DILI severity class index of 8.0, indicating potential toxicity concerns. In terms of antiviral activity, Alclofenac inhibits SARS-CoV-2 induced cytotoxicity across different cell types, albeit with relatively low efficacy. Notably, it shows an inhibition rate of 11.73% in Caco-2 cells at 10 µM after 48 hours and has an inhibition index of 0.1624 in Vero E6 cells. The compound has a hit score of 0.04614 when tested against the SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells. It also exhibits a minimal inhibition percentage of 0.6877% for the SARS-CoV-2 3CL-Pro protease at 20 µM and an IC50 value greater than 20000 nM in Vero-6 cells, illustrating the need for relatively high concentrations for effective inhibition. Moreover, Alclofenac shows inhibitory activity in an enzymatic assay for human HDAC6 with a 9.47% inhibition, although it shows a decrease in activity with a -1.22% inhibition using a custom peptide substrate. Across various assays and targets, it demonstrates a lack of significant bioactivity, with AC50 values above 30000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Alclofenac (W-7320) has a significant effect on the acute phase protein response and the degree of L-tryptophan binding to plasma protein and can be used in the treatment of patients with chronic rheumatism.
Synonyms	W-7320, W7320, W 7320, MY 101, BRN 2116510

Chemical Properties

Molecular Weight	226.66
Formula	C₁₁H₁₁ClO₃
Cas No.	22131-79-9
Smiles	C(C(O)=O)C1=CC(Cl)=C(OCC=C)C=C1
Relative Density.	1.2401 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14 mg/mL (61.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4119 mL	22.0595 mL	44.1189 mL	220.5947 mL
5 mM	0.8824 mL	4.4119 mL	8.8238 mL	44.1189 mL
10 mM	0.4412 mL	2.2059 mL	4.4119 mL	22.0595 mL
20 mM	0.2206 mL	1.1030 mL	2.2059 mL	11.0297 mL
50 mM	0.0882 mL	0.4412 mL	0.8824 mL	4.4119 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc