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(RS)-3-Hydroxyphenylglycine

Name: (RS)-3-Hydroxyphenylglycine
Brand: TargetMol
SKU: T23259
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23259Cas No. 31932-87-3

(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.

(RS)-3-Hydroxyphenylglycine

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Purity: 99.29%

Catalog No. T23259Cas No. 31932-87-3

(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$45	In Stock	In Stock
25 mg	$96	In Stock	In Stock
50 mg	$156	In Stock	In Stock
100 mg	$236	In Stock	In Stock
200 mg	$333	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

(RS)-3-Hydroxyphenylglycine AI Summary

(RS)-3-Hydroxyphenylglycine shows agonist activity against cloned human metabotropic glutamate receptor 1 (mGluR1) with a Ki of 1,000,000 nM and against cloned metabotropic glutamate receptor 5 (mGluR5) with a Ki of 14,000 nM. It does not exhibit significant agonist potency against cloned metabotropic glutamate receptor 2 (mGluR2) or metabotropic glutamate receptor 4 (mGluR4), with Ki values both greater than 1,000,000 nM. Additionally, (RS)-3-Hydroxyphenylglycine acts as a potent inhibitor in two distinct assays, demonstrating inhibitory activity against Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 37,650.5 nM and against Regulator of G Protein Signaling 4 (RGS4) with a potency of 133.7 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.

Chemical Properties

Molecular Weight	167.16
Formula	C₈H₉NO₃
Cas No.	31932-87-3
Smiles	NC(C(O)=O)c1cccc(O)c1
Relative Density.	1.396 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1eq. NaOH: 15 mg/mL (89.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	5.9823 mL	29.9115 mL	59.8229 mL	299.1146 mL
5 mM	1.1965 mL	5.9823 mL	11.9646 mL	59.8229 mL
10 mM	0.5982 mL	2.9911 mL	5.9823 mL	29.9115 mL
20 mM	0.2991 mL	1.4956 mL	2.9911 mL	14.9557 mL
50 mM	0.1196 mL	0.5982 mL	1.1965 mL	5.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc