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ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE
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Catalog No. T8603Cas No. 4815-38-7
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human)
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE
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Purity: 99.98%
Catalog No. T8603Cas No. 4815-38-7
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human)
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $37 | In Stock | - | |
| 25 mg | $66 | In Stock | - | |
| 50 mg | $98 | In Stock | - | |
| 100 mg | $148 | In Stock | - | |
| 200 mg | $221 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock | - |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE AI Summary
ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE exhibits antagonist activity at human recombinant GluR5 and GluR6 receptors, inhibiting glutamate-induced Ca2+ influx with an inhibition rate of 12.0% at GluR5 and an IC50 value of 750 nM for GluR6 at 10 µM. It has a broad spectrum of bioactivities, including inhibition of Tau fibril formation, ALDH1A1, Sfp phosphopantetheinyl transferase, HPGD, JMJD2A-Tudor Domain, HP1-beta Chromodomain interactions, RGS4, G9a, TDP1, TDP-43, and alpha-syn. It also activates miRNAs, including miR-21, increases BRCA1 expression, induces synthetic lethality in tumor cells, and acts as an agonist on EPAC1. Notably, ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE shows strong inhibition of SARS-CoV-2 3CL-Pro protease with an inhibition rate of 84.38% at 20 µM and an IC50 value of 3190 nM, while exhibiting minimal inhibition of chymotrypsin (5.82% at 10 µM). Additionally, it inhibits SARS-CoV-2-induced cytotoxicity in VERO-6 cells with an inhibition rate of 0.26% at 10 µM after 48 hours. In FRET assays, its IC50 for SARS-CoV-2 3CL-Pro protease inhibition is 3.281-3.607 µM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human) |
| Molecular Weight | 261.34 |
| Formula | C14H15NO2S |
| Cas No. | 4815-38-7 |
| Smiles | CCOC(=O)C1=C(N)SC(=C1C)C1=CC=CC=C1 |
| Relative Density. | 1.203g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (95.66 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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