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Lenalidomide-acetylene-Br is the PROTAC linker that makes up HJM-561. HJM-561 is an effective, selective, and orally active EGFR PROTAC that can inhibit the triple mutation of EGFR which is resistant to Osimertinib.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
| Description | Lenalidomide-acetylene-Br is the PROTAC linker that makes up HJM-561. HJM-561 is an effective, selective, and orally active EGFR PROTAC that can inhibit the triple mutation of EGFR which is resistant to Osimertinib. |
| Molecular Weight | 375.22 |
| Formula | C17H15BrN2O3 |
| Cas No. | 2619512-84-2 |
| Smiles | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(C#CCCBr)C3C2)CC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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