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CAY10583

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Catalog No. T26958Cas No. 862891-27-8
Alias CAY-10583, CAY 10583

CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.

CAY10583

CAY10583

😃Good
Catalog No. T26958Alias CAY-10583, CAY 10583Cas No. 862891-27-8
CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.
Pack SizePriceAvailabilityQuantity
5 mgTBD35 days
10 mgTBD35 days
25 mgTBD35 days
50 mgTBD35 days
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Product Introduction

Bioactivity
Description
CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.
In vitro
CAY10583 significantly activated AMPK in human hepatocellular carcinoma HepG2 cells. Treatment with 50 μM CAY10583 for 1 hour increased phosphorylation levels of AMPK and its downstream target ACC, indicating metabolic regulatory activity as an AMPK activator. CAY10583 also suppressed expression of lipogenesis-related proteins such as FAS and SREBP-1c[1].
In vivo
In high-fat diet–induced obese mice, CAY10583 was administered intraperitoneally at 10 mg/kg once daily for 4 weeks. The treatment significantly reduced body weight gain, serum total cholesterol, and triglyceride levels, and increased phosphorylation of AMPK and ACC in liver tissues, indicating lipid metabolism improvement and anti-obesity effects[1].
AliasCAY-10583, CAY 10583
Chemical Properties
Molecular Weight387.47
FormulaC25H25NO3
Cas No.862891-27-8
SmilesO=C(O)C=1C=CC=CC1C=2C=CC(=CC2)CN(C=3C=CC=CC3)C(=O)CCCC
Relative Density.1.177 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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