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CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | TBD | 35 days | |
10 mg | TBD | 35 days | |
25 mg | TBD | 35 days | |
50 mg | TBD | 35 days |
Description | CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice. |
In vitro | CAY10583 significantly activated AMPK in human hepatocellular carcinoma HepG2 cells. Treatment with 50 μM CAY10583 for 1 hour increased phosphorylation levels of AMPK and its downstream target ACC, indicating metabolic regulatory activity as an AMPK activator. CAY10583 also suppressed expression of lipogenesis-related proteins such as FAS and SREBP-1c[1]. |
In vivo | In high-fat diet–induced obese mice, CAY10583 was administered intraperitoneally at 10 mg/kg once daily for 4 weeks. The treatment significantly reduced body weight gain, serum total cholesterol, and triglyceride levels, and increased phosphorylation of AMPK and ACC in liver tissues, indicating lipid metabolism improvement and anti-obesity effects[1]. |
Alias | CAY-10583, CAY 10583 |
Molecular Weight | 387.47 |
Formula | C25H25NO3 |
Cas No. | 862891-27-8 |
Smiles | O=C(O)C=1C=CC=CC1C=2C=CC(=CC2)CN(C=3C=CC=CC3)C(=O)CCCC |
Relative Density. | 1.177 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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