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CAY10583
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Catalog No. T26958Cas No. 862891-27-8
Alias CAY-10583, CAY 10583
CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.
CAY10583
Copy Product Info😃Good
Catalog No. T26958Alias CAY-10583, CAY 10583Cas No. 862891-27-8
CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | - | In Stock | |
| 2 mg | $70 | 6-8 weeks | 6-8 weeks | |
| 5 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:>99.99%
Appearance:Solid
Color:White
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Product Introduction
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| Description | CAY10583 is a potent and selective BLT2 (leukotriene B4 receptor type 2) agonist that increases TGF-β1 and bFGF expression, promotes keratinocyte migration and fibroblast proliferation, and accelerates wound healing in diabetic mice. |
| In vitro | CAY10583 significantly activated AMPK in human hepatocellular carcinoma HepG2 cells. Treatment with 50 μM CAY10583 for 1 hour increased phosphorylation levels of AMPK and its downstream target ACC, indicating metabolic regulatory activity as an AMPK activator. CAY10583 also suppressed expression of lipogenesis-related proteins such as FAS and SREBP-1c[1]. |
| In vivo | In high-fat diet–induced obese mice, CAY10583 was administered intraperitoneally at 10 mg/kg once daily for 4 weeks. The treatment significantly reduced body weight gain, serum total cholesterol, and triglyceride levels, and increased phosphorylation of AMPK and ACC in liver tissues, indicating lipid metabolism improvement and anti-obesity effects[1]. |
| Synonyms | CAY-10583, CAY 10583 |
| Molecular Weight | 387.47 |
| Formula | C25H25NO3 |
| Cas No. | 862891-27-8 |
| Smiles | O=C(O)C=1C=CC=CC1C=2C=CC(=CC2)CN(C=3C=CC=CC3)C(=O)CCCC |
| Relative Density. | 1.177 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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