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3-(2-Hydroxyphenyl)-2-propenal

Name: 3-(2-Hydroxyphenyl)-2-propenal
Brand: TargetMol
SKU: TN2857
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2857 Copy Product Info

Purity: 99.83%

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3-(2-Hydroxyphenyl)-2-propenal is a natural phenylpropanal isolated from the bark of the cassia cinnamon (Cinnamomum cassia). 3-(2-Hydroxyphenyl)-2-propenal inhibits the proliferation of various tumor cells and induces apoptosis by directly binding to STAT3 and inhibiting its phosphorylation at Tyr705 and nuclear translocation, while simultaneously regulating the expression of downstream target genes by inhibiting the Wnt/β-catenin signaling pathway. (E)-2-Hydroxycinnamaldehyde possesses antitumor activity and can be used in tumor research.

Cas No. 60125-23-7

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Pack Size	Price	USA Stock	Global Stock
5 mg	$30	-	In Stock
10 mg	$41	-	In Stock
25 mg	$66	-	In Stock
50 mg	$95	-	In Stock
100 mg	$138	-	In Stock
1 mL x 10 mM (in DMSO)	$153	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	3-(2-Hydroxyphenyl)-2-propenal is a natural phenylpropanal isolated from the bark of the cassia cinnamon (Cinnamomum cassia). 3-(2-Hydroxyphenyl)-2-propenal inhibits the proliferation of various tumor cells and induces apoptosis by directly binding to STAT3 and inhibiting its phosphorylation at Tyr705 and nuclear translocation, while simultaneously regulating the expression of downstream target genes by inhibiting the Wnt/β-catenin signaling pathway. (E)-2-Hydroxycinnamaldehyde possesses antitumor activity and can be used in tumor research.
In vitro	Methods: DU145 prostate cancer cells were treated with 5–40 μM 3-(2-Hydroxyphenyl)-2-propenal for 24–48 h. Cell proliferation was assessed using the WST-1 assay, and STAT3 phosphorylation levels were detected by Western blot. Results: The GI₅₀ for DU145 cell proliferation was 20 μM; treatment with 20 μM 3-(2-hydroxyphenyl)-2-propenal for 30 min significantly inhibited STAT3 Tyr705 phosphorylation, with an inhibition rate >70% at 12 h, without altering total STAT3 protein levels.[1] Methods: DU145 cells were treated with 20 μM 3-(2-hydroxyphenyl)-2-propenal for 24–48 h; Western blot analysis was performed to detect STAT3 target gene expression; flow cytometry was used to analyze cell cycle distribution. Results: 3-(2-Hydroxyphenyl)-2-propenal significantly downregulated cell cycle genes (cyclin D1, cyclin A) and anti-apoptotic genes (Bcl-2, Bcl-xL, Mcl-1, survivin); G0/G1 phase arrest began to appear at 6 h, and the proportion of apoptotic cells (sub-G1 peak) significantly increased after 24 h.[1]
In vivo	Methods: Six-week-old female BALB/c nude mice were subcutaneously inoculated with 1×10⁶ DU145 cells and randomly assigned to treatment groups. They were administered 3-(2-hydroxyphenyl)-2-propenal orally at a dose of 50 mg/kg, five times a week for 25 consecutive days; Tumor volume and mouse body weight were measured twice weekly; at the end of the study, the mice were euthanized and tumor weight was measured. Results: 3-(2-Hydroxyphenyl)-2-propenal significantly inhibited tumor growth; compared with the control group, tumor volume decreased by 48.4% and tumor weight decreased by 49.5%. There was no significant decrease in mouse body weight during the treatment period, and no significant toxic reactions were observed.[1]

Chemical Properties

Molecular Weight	148.16
Formula	C₉H₈O₂
Cas No.	60125-23-7
Smiles	C(=C/C=O)\C1=C(O)C=CC=C1
Relative Density.	1.174 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 280 mg/mL (1889.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.7495 mL	33.7473 mL	67.4946 mL	337.4730 mL
5 mM	1.3499 mL	6.7495 mL	13.4989 mL	67.4946 mL
10 mM	0.6749 mL	3.3747 mL	6.7495 mL	33.7473 mL
20 mM	0.3375 mL	1.6874 mL	3.3747 mL	16.8737 mL
50 mM	0.1350 mL	0.6749 mL	1.3499 mL	6.7495 mL
100 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3747 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

3-(2-Hydroxyphenyl)-2-propenal3(2Hydroxyphenyl)2propenal3 (2 Hydroxyphenyl) 2 propenal

Related Tags: 3-(2-Hydroxyphenyl)-2-propenal chemical structure | 3-(2-Hydroxyphenyl)-2-propenal in vivo | 3-(2-Hydroxyphenyl)-2-propenal in vitro | 3-(2-Hydroxyphenyl)-2-propenal formula | 3-(2-Hydroxyphenyl)-2-propenal molecular weight