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Forsyshiyanine A

Catalog No. TN13227 Copy Product Info
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Foryshiyanine A is a triterpenoid alkaloid with notable biological activities. It exhibits anti-inflammatory properties by inhibiting β-glucuronidase release from rat polymorphonuclear leukocytes. Additionally, Foryshiyanine A demonstrates antiviral activity, with an EC50 value of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 value of 7.3 μM against the influenza A H1N1 virus. It reduces viral load by interfering with viral replication and entry, making it useful for studying inflammation and infection.

Forsyshiyanine A

Copy Product Info
🥰Excellent
Catalog No. TN13227

Foryshiyanine A is a triterpenoid alkaloid with notable biological activities. It exhibits anti-inflammatory properties by inhibiting β-glucuronidase release from rat polymorphonuclear leukocytes. Additionally, Foryshiyanine A demonstrates antiviral activity, with an EC50 value of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 value of 7.3 μM against the influenza A H1N1 virus. It reduces viral load by interfering with viral replication and entry, making it useful for studying inflammation and infection.

Forsyshiyanine A
Cas No. 2767053-65-4
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For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Foryshiyanine A is a triterpenoid alkaloid with notable biological activities. It exhibits anti-inflammatory properties by inhibiting β-glucuronidase release from rat polymorphonuclear leukocytes. Additionally, Foryshiyanine A demonstrates antiviral activity, with an EC50 value of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 value of 7.3 μM against the influenza A H1N1 virus. It reduces viral load by interfering with viral replication and entry, making it useful for studying inflammation and infection.
In vitro
Forsyshiyanine A (Compound 1) (10 μM) inhibits the release of β-glucuronidase from rat polymorphonuclear leukocytes with an inhibition rate of 54.5%. It exhibits strong antiviral activity against the influenza A virus (H1N1) with an IC50 value of 7.3 μM and shows significant activity against respiratory syncytial virus (RSV) with an EC50 value of 4.5 μM. Forsyshiyanine A, at concentrations ranging from 0.5 to 100 μg/mL, demonstrates no noticeable cytotoxicity in MDCK cells, maintaining cell viability above 80%. Additionally, Forsyshiyanine A (50 μM) does not show appreciable cytotoxic effects on five human tumor cell lines: A549 (lung cancer), A2058 (melanoma), HepG2 (liver cancer), MCF-7 (breast cancer), and Mia PaCa-2 (pancreatic cancer).
Chemical Properties
Molecular Weight259.39
FormulaC17H25NO
Cas No.2767053-65-4
SmilesC[C@@]12[C@]([C@](CO)(C)CCC1)(CCC=3C2=CC=C(C)N3)[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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