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Foryshiyanine A is a triterpenoid alkaloid with notable biological activities. It exhibits anti-inflammatory properties by inhibiting β-glucuronidase release from rat polymorphonuclear leukocytes. Additionally, Foryshiyanine A demonstrates antiviral activity, with an EC50 value of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 value of 7.3 μM against the influenza A H1N1 virus. It reduces viral load by interfering with viral replication and entry, making it useful for studying inflammation and infection.
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | Foryshiyanine A is a triterpenoid alkaloid with notable biological activities. It exhibits anti-inflammatory properties by inhibiting β-glucuronidase release from rat polymorphonuclear leukocytes. Additionally, Foryshiyanine A demonstrates antiviral activity, with an EC50 value of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 value of 7.3 μM against the influenza A H1N1 virus. It reduces viral load by interfering with viral replication and entry, making it useful for studying inflammation and infection. |
| In vitro | Forsyshiyanine A (Compound 1) (10 μM) inhibits the release of β-glucuronidase from rat polymorphonuclear leukocytes with an inhibition rate of 54.5%. It exhibits strong antiviral activity against the influenza A virus (H1N1) with an IC50 value of 7.3 μM and shows significant activity against respiratory syncytial virus (RSV) with an EC50 value of 4.5 μM. Forsyshiyanine A, at concentrations ranging from 0.5 to 100 μg/mL, demonstrates no noticeable cytotoxicity in MDCK cells, maintaining cell viability above 80%. Additionally, Forsyshiyanine A (50 μM) does not show appreciable cytotoxic effects on five human tumor cell lines: A549 (lung cancer), A2058 (melanoma), HepG2 (liver cancer), MCF-7 (breast cancer), and Mia PaCa-2 (pancreatic cancer). |
| Molecular Weight | 259.39 |
| Formula | C17H25NO |
| Cas No. | 2767053-65-4 |
| Smiles | C[C@@]12[C@]([C@](CO)(C)CCC1)(CCC=3C2=CC=C(C)N3)[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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