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4-tert-Octylphenol

Name: 4-tert-Octylphenol
Brand: TargetMol
SKU: T64353
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64353Cas No. 140-66-9

4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), thereby diminishing the proliferation of neuronal progenitors. Consequently, 4-tert-Octylphenol adversely affects brain development and behavior in mice.

4-tert-Octylphenol

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Purity: 99.77%

Catalog No. T64353Cas No. 140-66-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

4-tert-Octylphenol AI Summary

4-tert-Octylphenol demonstrates a diverse range of bioactivities. It shows the ability to displace [3H]5alpha dihydrotestosterone from human sex hormone binding globulin with a binding affinity of Kd = 2137.96 nM. In Wistar rat studies, at a dosage of 200 mg/kg, the compound achieves a drug level of 80.0 ng/ml in blood. Additionally, 4-tert-Octylphenol exhibits potency in inhibiting ROR gamma transcriptional activity, estrogen receptor alpha signaling, and both agonistic and antagonistic effects on thyroid hormone receptor beta signaling. It delays death inhibition of the malarial parasite and functions as a USP1/UAF1 inhibitor, inducing DNA re-replication in normal breast cells. The compound also activates the NF-kB signaling pathway, PPARalpha signaling pathway, and the pregnane X receptor (PXR) signaling pathway. Furthermore, it inhibits tyrosyl-DNA phosphodiesterase 1, and blocks entry of Lassa Virus, Marburg Virus, and Ebola Virus. It impacts VEGF-stimulated activities, ADSC/ECFC co-culture nuclear area, CD31-stained tube area, and GLP1 secretion, showcasing a breadth of effects across various cellular processes and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	206.32
Formula	C₁₄H₂₂O
Cas No.	140-66-9
Smiles	CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (218.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8468 mL	24.2342 mL	48.4684 mL	242.3420 mL
5 mM	0.9694 mL	4.8468 mL	9.6937 mL	48.4684 mL
10 mM	0.4847 mL	2.4234 mL	4.8468 mL	24.2342 mL
20 mM	0.2423 mL	1.2117 mL	2.4234 mL	12.1171 mL
50 mM	0.0969 mL	0.4847 mL	0.9694 mL	4.8468 mL
100 mM	0.0485 mL	0.2423 mL	0.4847 mL	2.4234 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc