Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YD23 is a SMARCA2 PROTAC that promotes SMARCA2 degradation, a process synthetically lethal to SMARCA4-deficient cells. It specifically diminishes chromatin accessibility at enhancers of various genes involved in cell cycle and growth regulation, exhibiting this activity exclusively in the absence of SMARCA4 [1] [2].
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Description | YD23 is a SMARCA2 PROTAC that promotes SMARCA2 degradation, a process synthetically lethal to SMARCA4-deficient cells. It specifically diminishes chromatin accessibility at enhancers of various genes involved in cell cycle and growth regulation, exhibiting this activity exclusively in the absence of SMARCA4 [1] [2]. |
Molecular Weight | 738.76 |
Formula | C38H39FN8O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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YD23 PROTAC PROTACs inhibitor inhibit