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MDH2-IN-2
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Catalog No. T217882 Copy Product Info
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MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 μM. It reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. Additionally, MDH2-IN-2 extends the lifespan and enhances the health span of Caenorhabditis elegans. In aged mice, MDH2-IN-2 alleviates tissue aging, inhibits SASP factors, and restores liver and kidney function. MDH2-IN-2 is applicable in aging-related research.
MDH2-IN-2
Cas No. 3047410-41-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 μM. It reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. Additionally, MDH2-IN-2 extends the lifespan and enhances the health span of Caenorhabditis elegans. In aged mice, MDH2-IN-2 alleviates tissue aging, inhibits SASP factors, and restores liver and kidney function. MDH2-IN-2 is applicable in aging-related research. |
| In vitro | MDH2-IN-2 (Compound 28i) inhibits the activity of recombinant human MDH1 enzyme with an IC50 of 25.3 μM. At 1 μM for 3 days, MDH2-IN-2 significantly downregulates mRNA levels of multiple SASP factors in MRC-5 cells, decreases p53 protein expression, and reduces the proportion of SA-β-gal-positive cells in replicative senescent MRC-5 cells. In NRK-52E cells, MDH2-IN-2 at 1 μM significantly lowers the proportion of SA-β-gal-positive cells induced by Mitomycin C. Additionally, at 1 μM over 5 days, it significantly decreases p16 protein expression and the proportion of SA-β-gal-positive cells in replicative senescent MEFs. Rapid metabolic turnover of MDH2-IN-2 is observed in both human and mouse liver microsomes, with half-lives of 1.15 min and 1.10 min, respectively, at concentrations ranging from 5 to 60 minutes. |
| In vivo | MDH2-IN-2, when used at a concentration of 100 μM incorporated into NGM plates for continuous exposure, can extend the average lifespan of wild-type Caenorhabditis elegans by 15.49% and improve various health-related indicators. Additionally, MDH2-IN-2 administered at 0-50 mg/kg (intraperitoneal, once daily for 3 weeks) significantly inhibits multiple SASP factors in doxorubicin-induced progeroid male C57BL/6J mice. In another study, daily intraperitoneal administration of MDH2-IN-2 at doses of 5-10 mg/kg for 3 months in naturally aging male C57BL/6J mice was found to reverse age-related serum biochemical abnormalities, suppress the production of SASP factors, reduce the expression of renal aging markers, and improve renal histological morphology. |
| Molecular Weight | 536.73 |
| Formula | C31H40N2O4S |
| Cas No. | 3047410-41-0 |
| Smiles | O=C(NCCC1=CC=C(C=C1)S(=O)(=O)NC23CC4CC(CC(C4)C2)C3)C=5C=CC=C(OCC6CCCC6)C5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: MDH2-IN-2 in vivo | MDH2-IN-2 in vitro | MDH2-IN-2 formula | MDH2-IN-2 molecular weight
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