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PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-induced hypernociception in rats.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | TBD | 35 days |
Description | PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-induced hypernociception in rats. |
Targets&IC50 | C5aR:20 nM (IC50) |
Alias | PMX53, PMX 53 |
Molecular Weight | 896.09 |
Formula | C47H65N11O7 |
Cas No. | 219639-75-5 |
Relative Density. | 1.40 g/cm3 (Predicted) |
Sequence | Ac-Phe-{Orn}-Pro-{dCha}-Trp-Arg (Lactam bridge: Orn2-Arg6) |
Sequence Short | Ac-F-{Orn}-P-{dCha}-WR (Lactam bridge: Orn2-Arg6) |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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