Shopping Cart

Your shopping cart is currently empty

Cladosporin

Name: Cladosporin
Brand: TargetMol
SKU: T69369
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T69369 Copy Product Info

🥰Excellent

Cladosporin is a metabolite derived from the mycelium of Cladosporium cladosporioides. Cladosporin inhibits the growth of several dermatophytes on agar medium at a concentration of 75 µg/mL, demonstrating potent antifungal activity. The biological properties of Cladosporin support the utilization of Cladosporin in studies of fungal biology, natural product research, antifungal mechanism characterization, and microbial growth regulation.

Cas No. 35818-31-6

Pack Size	Price	USA Stock	Global Stock	Quantity
500 µg	$163	-	In Stock
1 mg	$263	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

In vitro

Method: Recombinant Plasmodium falciparum cytoplasmic lysyl-tRNA synthetase and human lysyl-tRNA synthetase were tested in aminoacylation assays with cladosporin.[1]
Rresult: Cladosporin inhibited the P. falciparum enzyme with an IC50 of approximately 61 nM, whereas the human enzyme had an IC50 greater than 20 μM, demonstrating marked biochemical selectivity.[1]
Method: Cladosporin was tested against Plasmodium blood-stage and liver-stage parasites, with HepG2-CD81 cells used to assess host-cell toxicity.[1]
Rresult: Parasite growth was inhibited at approximately 40-90 nM, whereas toxicity to HepG2-CD81 host cells was not detected below 10 μM, providing a large parasite-versus-host selectivity window.[1]

Chemical Properties

Molecular Weight	292.33
Formula	C₁₆H₂₀O₅
Cas No.	35818-31-6
Smiles	O=C1C=2C(C[C@H](C[C@@H]3O[C@@H](C)CCC3)O1)=CC(O)=CC2O

Storage & Solubility Information

Storage

Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (68.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4208 mL	17.1040 mL	34.2079 mL	171.0396 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL	34.2079 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
20 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4208 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc