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BNTA

Catalog No. T40795 CAS 685119-25-9

BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxide dismutase 3 (SOD3) and regulating chondrogenesis through superoxide anion elimination.

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BNTA, CAS 685119-25-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 637.00
50 mg	In stock	$ 892.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.87%

Purity: 99.34%

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Description	BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxide dismutase 3 (SOD3) and regulating chondrogenesis through superoxide anion elimination.
In vitro	BNTA (0.01-10 μM; 1-7 days) exhibits no reduction in cell viability for human osteoarthritis chondrocytes and primary chondrocytes isolated from rats.[1] BNTA (0.1 μM; 2 days) induces a significant elevation in SOX9 protein expression. Notably, BNTA markedly enhances the protein levels of COL2A1 and SOX9 in rat osteoarthritis (OA) chondrocytes induced by IL1β.[1] BNTA (0.01-10 μM; 6 hours) enhances the expression levels of extracellular matrix (ECM)-related genes, including COL2A1, ACAN, proteoglycan 4 (PRG4), and SRY-box 9 (SOX9) in human osteoarthritis (OA) chondrocytes. In IL1β-induced rat OA chondrocytes, BNTA elevates Col2a1, Acan, Prg4, and Sox9 mRNA levels, with the most significant effects observed around 0.1 μM.[1] BNTA (10 μM; 5 days) increases proteoglycan staining in ATDC5 cells.[1] BNTA (0.01-1 μM; 2 or 3 weeks) enhances anabolism and inhibits inflammatory response in osteoarthritis cartilage explants.[1]
In vivo	BNTA (0.015-1.5 mg/kg; intra-articular injection; twice a week for 4 and 8 weeks; Male SD rats ) attenuated post-traumatic osteoarthritis development after intra-articular injection well tolerated and could attenuate OA progression developed after anterior cruciate ligament transection (ACLT) in rats.[1]

Molecular Weight	456.76
Formula	C17H11BrClNO3S2
CAS No.	685119-25-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (175.15 mM), Sonication is recommended.

References and Literature

1. Shi Y, et, al. A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat Commun. 2019 Apr 23; 10(1): 1914.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

BNTA 685119-25-9 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibitor inhibit

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