ATP dipotassium

Name: ATP dipotassium
Brand: TargetMol
SKU: T40526
Rating: 4.5 (1 reviews)

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Catalog No. T40526Cas No. 42373-41-1

Alias Adenosine5'-triphosphatedipotassium

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms, supplying metabolic energy for driving pumps and acting as a coenzyme in cellular processes, while also functioning as a significant endogenous signaling molecule contributing to immunity and inflammation.

ATP dipotassium

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Catalog No. T40526Alias Adenosine5'-triphosphatedipotassiumCas No. 42373-41-1

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Product Introduction

Bioactivity

Description	ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms, supplying metabolic energy for driving pumps and acting as a coenzyme in cellular processes, while also functioning as a significant endogenous signaling molecule contributing to immunity and inflammation.
In vitro	Co-treatment of ATP dipotassium (5 mM; 1 hour) with LPS (1 µg/mL) synergistically activates the NLRP3 inflammasome in HGFs[3]. Additionally, ATP dipotassium (2 mM; 0.5-24 hours) facilitates the secretion of IL-1β, KC, and MIP-2 from BMDMs through a mechanism dependent on caspase-1 activation[4]. Furthermore, ATP dipotassium enhances neutrophil chemotaxis in vitro[4].
In vivo	ATP dipotassium (50 mg/kg; i.p.) exhibits protective effects against bacterial (E. coli) infection in four-week-old Kunming mice (18-22 g) by inducing IL-1β, KC, and MIP-2 secretion and recruiting neutrophils in vivo[4]. Administered via intraperitoneal injection at 50 mg/kg prior to E. coli challenge, it effectively safeguards mice from bacterial invasion[4].
Synonyms	Adenosine5'-triphosphatedipotassium

Chemical Properties

Molecular Weight	583.36
Formula	C₁₀H₁₄K₂N₅O₁₃P₃
Cas No.	42373-41-1
Smiles	[K].Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc