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Guanosine 5'-triphosphate-5'-adenosine

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Catalog No. T38449Cas No. 10527-47-6
Alias Guanosine 5'-triphosphate-5'-adenosine, GpppA

Guanosine 5'-triphosphate-5'-adenosine, known as a 5′ cap analog, serves as a fluorescent substrate analog.

Guanosine 5'-triphosphate-5'-adenosine

Guanosine 5'-triphosphate-5'-adenosine

😃Good
Catalog No. T38449Alias Guanosine 5'-triphosphate-5'-adenosine, GpppACas No. 10527-47-6
Guanosine 5'-triphosphate-5'-adenosine, known as a 5′ cap analog, serves as a fluorescent substrate analog.
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Product Introduction

Bioactivity
Description
Guanosine 5'-triphosphate-5'-adenosine, known as a 5′ cap analog, serves as a fluorescent substrate analog.
In vitro
Guanosine 5'-triphosphate-5'-adenosine (GpppA), labeled with pyrene at the adenosine's 3'-O position, acts as an artificial substrate. This fluorescent labeling of GpppA, along with GpppG analogs, effectively matches the enzyme’s structural complexity and functional needs [1].
SynonymsGuanosine 5'-triphosphate-5'-adenosine, GpppA
Chemical Properties
Molecular Weight772.41
FormulaC20H27N10O17P3
Cas No.10527-47-6
SmilesNc1nc(=O)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2[nH]1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Guanosine 5'triphosphate5'adenosineGuanosine 5' triphosphate 5' adenosine
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